6-[[2-(acetylthio)-1-oxo-3-phenylpropyl]amino]hexahydro-2,2-dimethyl-7-oxo-1H-azepine-1-acetic acid

Base Information

Chemical Name:6-[[2-(acetylthio)-1-oxo-3-phenylpropyl]amino]hexahydro-2,2-dimethyl-7-oxo-1H-azepine-1-acetic acid
CAS No.:229976-40-3
Molecular Formula:C₂₁H₂₈N₂O₅S
Molecular Weight:420.53
Hs Code.:

Synonyms:6-[[2-(acetylthio)-1-oxo-3-phenylpropyl]amino]hexahydro-2,2-dimethyl-7-oxo-1H-azepine-1-acetic acid

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Chemical Property of 6-[[2-(acetylthio)-1-oxo-3-phenylpropyl]amino]hexahydro-2,2-dimethyl-7-oxo-1H-azepine-1-acetic acid

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Technology Process of 6-[[2-(acetylthio)-1-oxo-3-phenylpropyl]amino]hexahydro-2,2-dimethyl-7-oxo-1H-azepine-1-acetic acid

There total 10 articles about 6-[[2-(acetylthio)-1-oxo-3-phenylpropyl]amino]hexahydro-2,2-dimethyl-7-oxo-1H-azepine-1-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 229976-39-0
6-[[2-(acetylthio)-1-oxo-3-phenylpropyl]amino]hexahydro-2,2-dimethyl-7-oxo-1H-azepine-1-acetic acid 1,1-dimethylethyl ester

: 229976-40-3
6-[[2-(acetylthio)-1-oxo-3-phenylpropyl]amino]hexahydro-2,2-dimethyl-7-oxo-1H-azepine-1-acetic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 25 ℃; for 5h;
DOI:10.1021/ol0352308

Reference yield:

: 606147-29-9
(S)-hexahydro-2,2-dimethyl-7-oxo-6-[(phenylmethoxy)carbonylamino]-1H-azepine-1-acetic acid 1,1-dimethylethyl ester

: 229976-40-3
6-[[2-(acetylthio)-1-oxo-3-phenylpropyl]amino]hexahydro-2,2-dimethyl-7-oxo-1H-azepine-1-acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / H₂ / Pd(OH)2 / methanol / 4 h

2: 93 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / CH₂Cl₂ / 2.5 h

3: 93 percent / CF₃CO₂H / CH₂Cl₂ / 5 h / 25 °C

With hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; palladium dihydroxide; In methanol; dichloromethane;
DOI:10.1021/ol0352308

Reference yield:

: N⁶-[2-(1,1-dimethylethoxy)-2-oxoethyl]-6,6-dimethyl-N²-[(phenylmethoxy)carbonyl]-L-lysine monohydrochloride

: 229976-40-3
6-[[2-(acetylthio)-1-oxo-3-phenylpropyl]amino]hexahydro-2,2-dimethyl-7-oxo-1H-azepine-1-acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 92 percent / 1-hydroxybenzotriazole monohydrate; diisopropylethyl amine; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / acetonitrile / 2 h / 20 °C

2: 92 percent / H₂ / Pd(OH)2 / methanol / 4 h

3: 93 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / CH₂Cl₂ / 2.5 h

4: 93 percent / CF₃CO₂H / CH₂Cl₂ / 5 h / 25 °C

With hydrogen; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium dihydroxide; In methanol; dichloromethane; acetonitrile;
DOI:10.1021/ol0352308