4-[4-(4-cyano-benzoyl)-1,9b-dihydro-5-oxa-3,3a-diaza-cyclopenta[a]naphthalen-2-yl]-benzyl alcohol

Base Information

Chemical Name:4-[4-(4-cyano-benzoyl)-1,9b-dihydro-5-oxa-3,3a-diaza-cyclopenta[a]naphthalen-2-yl]-benzyl alcohol
CAS No.:912819-58-0
Molecular Formula:C₂₅H₁₉N₃O₃
Molecular Weight:409.444
Hs Code.:

Synonyms:4-[4-(4-cyano-benzoyl)-1,9b-dihydro-5-oxa-3,3a-diaza-cyclopenta[a]naphthalen-2-yl]-benzyl alcohol

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Chemical Property of 4-[4-(4-cyano-benzoyl)-1,9b-dihydro-5-oxa-3,3a-diaza-cyclopenta[a]naphthalen-2-yl]-benzyl alcohol

Chemical Property:

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Technology Process of 4-[4-(4-cyano-benzoyl)-1,9b-dihydro-5-oxa-3,3a-diaza-cyclopenta[a]naphthalen-2-yl]-benzyl alcohol

There total 6 articles about 4-[4-(4-cyano-benzoyl)-1,9b-dihydro-5-oxa-3,3a-diaza-cyclopenta[a]naphthalen-2-yl]-benzyl alcohol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 4-[5-(2-hydroxy-phenyl)-4,5-dihydro-1H-pyrazol-3-yl]-benzyl alcohol

: 20099-53-0
4-cyanophenylglyoxal

: 912819-58-0
4-[4-(4-cyano-benzoyl)-1,9b-dihydro-5-oxa-3,3a-diaza-cyclopenta[a]naphthalen-2-yl]-benzyl alcohol

Guidance literature:: toluene-4-sulfonic acid; In tetrahydrofuran; toluene; at 80 ℃; for 1.5h;

Reference yield:

: 912819-56-8
4-[3-(2-hydroxy-phenyl)-acryloyl]-benzyl alcohol

: 912819-58-0
4-[4-(4-cyano-benzoyl)-1,9b-dihydro-5-oxa-3,3a-diaza-cyclopenta[a]naphthalen-2-yl]-benzyl alcohol

Guidance literature:: Multi-step reaction with 2 steps

1: hydrazine / ethanol / 2 h / 20 °C

2: toluene-4-sulfonic acid / tetrahydrofuran; toluene / 1.5 h / 80 °C

With hydrazine; toluene-4-sulfonic acid; In tetrahydrofuran; ethanol; toluene;

Reference yield:

: 3457-45-2
p-formylacetophenone

: 912819-58-0
4-[4-(4-cyano-benzoyl)-1,9b-dihydro-5-oxa-3,3a-diaza-cyclopenta[a]naphthalen-2-yl]-benzyl alcohol

Guidance literature:: Multi-step reaction with 5 steps

1: sodium tris(acetoxy)borohydride / dichloroethylene, 1,2- / 7 h / Heating / reflux

2: potassium hydroxide / ethanol; water / 20 h / 20 °C

3: hydrogenchloride; water / tetrahydrofuran / 20 h / Heating / reflux

4: hydrazine / ethanol / 2 h / 20 °C

5: toluene-4-sulfonic acid / tetrahydrofuran; toluene / 1.5 h / 80 °C

With hydrogenchloride; potassium hydroxide; water; sodium tris(acetoxy)borohydride; hydrazine; toluene-4-sulfonic acid; In tetrahydrofuran; dichloroethylene, 1,2-; ethanol; water; toluene;