methyl 2-ethyl-1-(2-iodobenzyl)-2-trimethylsilyloxycyclopropane carboxylate

Base Information

Chemical Name:methyl 2-ethyl-1-(2-iodobenzyl)-2-trimethylsilyloxycyclopropane carboxylate
CAS No.:1260499-04-4
Molecular Formula:C₁₇H₂₅IO₃Si
Molecular Weight:432.374
Hs Code.:

Synonyms:methyl 2-ethyl-1-(2-iodobenzyl)-2-trimethylsilyloxycyclopropane carboxylate

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Chemical Property of methyl 2-ethyl-1-(2-iodobenzyl)-2-trimethylsilyloxycyclopropane carboxylate

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Technology Process of methyl 2-ethyl-1-(2-iodobenzyl)-2-trimethylsilyloxycyclopropane carboxylate

There total 1 articles about methyl 2-ethyl-1-(2-iodobenzyl)-2-trimethylsilyloxycyclopropane carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 4622-38-2
2-iodobenzyliodide

: 106711-00-6
2-Ethyl-2-(trimethylsiloxy)-1-cyclopropancarbonsaeure-methylester

: 1260499-04-4
methyl 2-ethyl-1-(2-iodobenzyl)-2-trimethylsilyloxycyclopropane carboxylate

Guidance literature:: 2-Ethyl-2-(trimethylsiloxy)-1-cyclopropancarbonsaeure-methylester; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 2h; Inert atmosphere;

2-iodobenzyliodide; In tetrahydrofuran; at -78 ℃; for 36h; Inert atmosphere;
DOI:10.3762/bjoc.6.141

Reference yield: 73.0%

: 1260499-04-4
methyl 2-ethyl-1-(2-iodobenzyl)-2-trimethylsilyloxycyclopropane carboxylate

: 1190211-35-8
methyl 2-(2-iodobenzyl)-4-oxohexanoate

Guidance literature:: With triethylamine tris(hydrogen fluoride); In dichloromethane; at 20 ℃; Inert atmosphere;
DOI:10.3762/bjoc.6.141

Reference yield:

: 1260499-04-4
methyl 2-ethyl-1-(2-iodobenzyl)-2-trimethylsilyloxycyclopropane carboxylate

: 1190211-39-2
methyl 4-oxo-2-{2-[(1E)-propen-1-yl]benzyl}hexanoate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine tris(hydrogen fluoride) / dichloromethane / 20 °C / Inert atmosphere

2: palladium diacetate; potassium carbonate; triphenylphosphine / N,N-dimethyl-formamide / 12 h / 70 °C / Inert atmosphere; Sealed vessel

With palladium diacetate; potassium carbonate; triethylamine tris(hydrogen fluoride); triphenylphosphine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.3762/bjoc.6.141