^tBOC-(S)-Ala-ΔPhe-(S)-Leu-OMe

Base Information

• Chemical Name: ^tBOC-(S)-Ala-ΔPhe-(S)-Leu-OMe
• CAS No.: 116908-51-1
• Molecular Formula: C₂₄H₃₅N₃O₆
• Molecular Weight: 461.558
• Mol file: 116908-51-1.mol

Synonyms:^tBOC-(S)-Ala-ΔPhe-(S)-Leu-OMe

Chemical Property of ^tBOC-(S)-Ala-ΔPhe-(S)-Leu-OMe

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ^tBOC-(S)-Ala-ΔPhe-(S)-Leu-OMe

There total 10 articles about ^tBOC-(S)-Ala-ΔPhe-(S)-Leu-OMe which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

methyl (L)-leucinate hydrochloride (7517-19-3) + Boc-Ala-ΔZPhe azlactone (116908-50-0) → tBOC-(S)-Ala-ΔPhe-(S)-Leu-OMe (116908-51-1)

Guidance literature:

With triethylamine; In chloroform; 1 h, 0 deg C then 40 h, 25 deg C;

DOI:10.1016/S0040-4020(01)82412-1

Reference yield: 67.0%

methyl (L)-leucinate hydrochloride (7517-19-3) + Boc-Ala-ΔZPhe-OH → tBOC-(S)-Ala-ΔPhe-(S)-Leu-OMe (116908-51-1)

Guidance literature:

With TEA; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; 0 deg C, 4 h; room temp., overnight;

DOI:10.1016/S0040-4020(01)80805-X

Reference yield:

L-N-Boc-Ala (15761-38-3) → tBOC-(S)-Ala-ΔPhe-(S)-Leu-OMe (116908-51-1)

Guidance literature:

Multi-step reaction with 2 steps

1: DCC / pyridine

2: methanol

With dicyclohexyl-carbodiimide; In pyridine; methanol;

DOI:10.1246/cl.1989.459

upstream raw materials:

(S)-Leu-OMe

Boc-L-Ala-(Z)-ΔPhe*NCA

methyl (L)-leucinate hydrochloride

Boc-Ala-Δ^ZPhe azlactone

Downstream raw materials:

{(S)-1-[(R)-1-((S)-1-Carbamoyl-3-methyl-butylcarbamoyl)-2-phenyl-ethylcarbamoyl]-ethyl}-carbamic acid tert-butyl ester

^tBOC-(S)-Ala-ΔPhe-(S)-Leu-NH2

Boc-Ala-Phe-Leu-NH₂

Boc-L-Ala-D-Phe-L-Leu-OMe