Fmoc(BocApi)2OBn

Base Information

• Chemical Name: Fmoc(BocApi)2OBn
• CAS No.: 1246024-65-6
• Molecular Formula: C₄₄H₅₄N₄O₉
• Molecular Weight: 782.934
• Mol file: 1246024-65-6.mol

Synonyms:Fmoc(BocApi)2OBn

Chemical Property of Fmoc(BocApi)2OBn

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of Fmoc(BocApi)2OBn

There total 1 articles about Fmoc(BocApi)2OBn which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

H(BocApi)OBn (1246024-64-5) + N-Fmoc-amino-(4-N-Boc-piperidinyl)carboxylic acid (183673-66-7) → Fmoc(BocApi)2OBn (1246024-65-6)

Guidance literature:

N-Fmoc-amino-(4-N-Boc-piperidinyl)carboxylic acid; With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 ℃; for 0.5h;

H(BocApi)OBn; With 2,4,6-trimethyl-pyridine; In dichloromethane; at 0 - 20 ℃;

DOI:10.1021/ja106118w

Reference yield: 97.0%

Fmoc(BocApi)2OBn (1246024-65-6) → H(BocApi)2OBn (1246024-67-8)

Guidance literature:

With diethylamine; In tetrahydrofuran;

DOI:10.1021/ja106118w

Reference yield:

Fmoc(BocApi)2OBn (1246024-65-6) → H(BocApi)4OBn (1246024-70-3)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogen; palladium on activated carbon / methanol; tetrahydrofuran / 760.05 Torr

2: 1-hydroxy-7-aza-benzotriazole / dichloromethane

3: diethylamine / tetrahydrofuran

With 1-hydroxy-7-aza-benzotriazole; palladium on activated carbon; hydrogen; diethylamine; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1002/chem.201605460

upstream raw materials:

H(BocApi)OBn

N-Fmoc-amino-(4-N-Boc-piperidinyl)carboxylic acid

Downstream raw materials:

H(BocApi)2OBn

H(BocApi)4OBn