N-[2(S)-(1,1-Dimethylethoxycarbonylamino)-3(S)-methylpentyl]-N-benzylglycyl-methionine methyl ester

Base Information

Chemical Name:N-[2(S)-(1,1-Dimethylethoxycarbonylamino)-3(S)-methylpentyl]-N-benzylglycyl-methionine methyl ester
CAS No.:178270-38-7
Molecular Formula:C₂₆H₄₃N₃O₅S
Molecular Weight:509.711
Hs Code.:

Synonyms:N-[2(S)-(1,1-Dimethylethoxycarbonylamino)-3(S)-methylpentyl]-N-benzylglycyl-methionine methyl ester

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Chemical Property of N-[2(S)-(1,1-Dimethylethoxycarbonylamino)-3(S)-methylpentyl]-N-benzylglycyl-methionine methyl ester

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Technology Process of N-[2(S)-(1,1-Dimethylethoxycarbonylamino)-3(S)-methylpentyl]-N-benzylglycyl-methionine methyl ester

There total 5 articles about N-[2(S)-(1,1-Dimethylethoxycarbonylamino)-3(S)-methylpentyl]-N-benzylglycyl-methionine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 118171-79-2,141321-51-9,141321-54-2,87694-55-1
N-(t-butoxycarbonyl)-isoleucine aldehyde

: 178270-38-7
N-[2(S)-(1,1-Dimethylethoxycarbonylamino)-3(S)-methylpentyl]-N-benzylglycyl-methionine methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 54 percent / Na(OAc)3BH, Et₃N, 3A molecular sieves / 1,2-dichloro-ethane; dimethylformamide / 18 h

2: Na(OAc)3BH, 3A molecular sieves / 1,2-dichloro-ethane / Ambient temperature

3: 1 N aq. NaOH / methanol / Ambient temperature

4: HOBT, EDC, Et₃N / dimethylformamide / Ambient temperature

With sodium hydroxide; 3 A molecular sieve; sodium tris(acetoxy)borohydride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In methanol; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1021/jm9800907

Reference yield:

: 168539-97-7
N-(2(S)-(t-butoxycarbonylamino)-3(S)-methylpentyl)glycine methyl ester

: 178270-38-7
N-[2(S)-(1,1-Dimethylethoxycarbonylamino)-3(S)-methylpentyl]-N-benzylglycyl-methionine methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: Na(OAc)3BH, 3A molecular sieves / 1,2-dichloro-ethane / Ambient temperature

2: 1 N aq. NaOH / methanol / Ambient temperature

3: HOBT, EDC, Et₃N / dimethylformamide / Ambient temperature

With sodium hydroxide; 3 A molecular sieve; sodium tris(acetoxy)borohydride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In methanol; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1021/jm9800907

Reference yield:

: 1026557-02-7
[Benzyl-((2S,3S)-2-tert-butoxycarbonylamino-3-methyl-pentyl)-amino]-acetic acid methyl ester

: 178270-38-7
N-[2(S)-(1,1-Dimethylethoxycarbonylamino)-3(S)-methylpentyl]-N-benzylglycyl-methionine methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1 N aq. NaOH / methanol / Ambient temperature

2: HOBT, EDC, Et₃N / dimethylformamide / Ambient temperature

With sodium hydroxide; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm9800907