methyl 1-methyl-2-[4-(trifluoromethoxy)phenyl]-1H-imidazole-5-carboxylate

Base Information

• Chemical Name: methyl 1-methyl-2-[4-(trifluoromethoxy)phenyl]-1H-imidazole-5-carboxylate
• CAS No.: 1202942-05-9
• Molecular Formula: C₁₃H₁₁F₃N₂O₃
• Molecular Weight: 300.237
• Mol file: 1202942-05-9.mol

Synonyms:methyl 1-methyl-2-[4-(trifluoromethoxy)phenyl]-1H-imidazole-5-carboxylate

Chemical Property of methyl 1-methyl-2-[4-(trifluoromethoxy)phenyl]-1H-imidazole-5-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of methyl 1-methyl-2-[4-(trifluoromethoxy)phenyl]-1H-imidazole-5-carboxylate

There total 1 articles about methyl 1-methyl-2-[4-(trifluoromethoxy)phenyl]-1H-imidazole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

2-bromo-3-methyl-3H-imidazole-4-carboxylic acid methyl ester (120781-02-4) + 4-trifluoromethoxyphenylboronic acid (139301-27-2) → methyl 1-methyl-2-[4-(trifluoromethoxy)phenyl]-1H-imidazole-5-carboxylate (1202942-05-9)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; In ethanol; water; toluene; Inert atmosphere; Reflux;

DOI:10.1021/jm901378u

Reference yield: 90.0%

methyl 1-methyl-2-[4-(trifluoromethoxy)phenyl]-1H-imidazole-5-carboxylate (1202942-05-9) → {1-methyl-2-[4-(trifluoromethoxy)phenyl]-1H-imidazol-5-yl}methanol (1202942-10-6)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 1h;

DOI:10.1021/jm901378u

upstream raw materials:

2-bromo-3-methyl-3H-imidazole-4-carboxylic acid methyl ester

4-trifluoromethoxyphenylboronic acid

Downstream raw materials:

{1-methyl-2-[4-(trifluoromethoxy)phenyl]-1H-imidazol-5-yl}methanol