N-{1-[bis(4-chlorophenyl)methyl]azetidin-3-yl}-N-(3,5-difluorophenyl)methylsulphonamide

Base Information

Chemical Name:N-{1-[bis(4-chlorophenyl)methyl]azetidin-3-yl}-N-(3,5-difluorophenyl)methylsulphonamide
CAS No.:358971-20-7
Molecular Formula:C₂₄H₂₂Cl₂F₂N₂O₂S
Molecular Weight:511.42
Hs Code.:

Synonyms:N-{1-[bis(4-chlorophenyl)methyl]azetidin-3-yl}-N-(3,5-difluorophenyl)methylsulphonamide

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Chemical Property of N-{1-[bis(4-chlorophenyl)methyl]azetidin-3-yl}-N-(3,5-difluorophenyl)methylsulphonamide

Chemical Property:

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Technology Process of N-{1-[bis(4-chlorophenyl)methyl]azetidin-3-yl}-N-(3,5-difluorophenyl)methylsulphonamide

There total 6 articles about N-{1-[bis(4-chlorophenyl)methyl]azetidin-3-yl}-N-(3,5-difluorophenyl)methylsulphonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 358971-49-0
1-[bis(4-chlorophenyl)methyl]azetidin-3-yl methanesulphonate

: N-(3,5-difluorophenyl)methylsulphonamide

: 358971-20-7
N-{1-[bis(4-chlorophenyl)methyl]azetidin-3-yl}-N-(3,5-difluorophenyl)methylsulphonamide

Guidance literature:: With potassium carbonate; In methylpentan-2-one; 4-; at 105 ℃; for 4h;

Reference yield:

: 90-98-2
4,4'-Dichlorobenzophenone

: 358971-20-7
N-{1-[bis(4-chlorophenyl)methyl]azetidin-3-yl}-N-(3,5-difluorophenyl)methylsulphonamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: toluene-4-sulfonic acid / ethanol; xylene / 20 - 140 °C / Inert atmosphere

2.1: sodium tetrahydroborate / water; xylene / 20 - 102 °C

2.2: 20 - 22 °C

2.3: pH 8 - 9

3.1: pyridine / toluene / -7 - 20 °C / Inert atmosphere

4.1: sodium hydrogencarbonate / toluene / 4 h / 79 °C

4.2: 20 °C

5.1: triethylamine / methylpentan-2-one; 4- / -12 - 20 °C / Inert atmosphere

6.1: potassium carbonate / methylpentan-2-one; 4- / 4 h / 105 °C

With pyridine; sodium tetrahydroborate; sodium hydrogencarbonate; potassium carbonate; toluene-4-sulfonic acid; triethylamine; In ethanol; methylpentan-2-one; 4-; water; toluene; xylene;

Reference yield:

: 1161418-95-6
3-{[bis(4-chlorophenyl)methylene]amino}propane-1,2-diol

: 358971-20-7
N-{1-[bis(4-chlorophenyl)methyl]azetidin-3-yl}-N-(3,5-difluorophenyl)methylsulphonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium tetrahydroborate / water; xylene / 20 - 102 °C

1.2: 20 - 22 °C

1.3: pH 8 - 9

2.1: pyridine / toluene / -7 - 20 °C / Inert atmosphere

3.1: sodium hydrogencarbonate / toluene / 4 h / 79 °C

3.2: 20 °C

4.1: triethylamine / methylpentan-2-one; 4- / -12 - 20 °C / Inert atmosphere

5.1: potassium carbonate / methylpentan-2-one; 4- / 4 h / 105 °C

With pyridine; sodium tetrahydroborate; sodium hydrogencarbonate; potassium carbonate; triethylamine; In methylpentan-2-one; 4-; water; toluene; xylene;