(1S,2S)-1-chloro-1-(4-fluorophenyl)-3-methylbutan-2-amine hydrochloride

Base Information

Chemical Name:(1S,2S)-1-chloro-1-(4-fluorophenyl)-3-methylbutan-2-amine hydrochloride
CAS No.:1421014-04-1
Molecular Formula:C₁₁H₁₅ClFN*ClH
Molecular Weight:252.159
Hs Code.:

Synonyms:(1S,2S)-1-chloro-1-(4-fluorophenyl)-3-methylbutan-2-amine hydrochloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1S,2S)-1-chloro-1-(4-fluorophenyl)-3-methylbutan-2-amine hydrochloride

Chemical Property:

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Technology Process of (1S,2S)-1-chloro-1-(4-fluorophenyl)-3-methylbutan-2-amine hydrochloride

There total 2 articles about (1S,2S)-1-chloro-1-(4-fluorophenyl)-3-methylbutan-2-amine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (1R,2S)-2-amino-1-(4-fluorophenyl)-3-methylbutan-1-ol hydrochloride

: 1421014-04-1
(1S,2S)-1-chloro-1-(4-fluorophenyl)-3-methylbutan-2-amine hydrochloride

: 1421014-07-4
(1R,2S)-1-chloro-1-(4-fluorophenyl)-3-methylbutan-2-amine hydrochloride

Guidance literature:: With thionyl chloride; In toluene; at 0 - 40 ℃; for 15h;
DOI:10.1016/j.tetlet.2012.11.079

Reference yield:

: (1S,2S)-2-(dibenzylamino)-1-(4-fluorophenyl)-3-methylbutan-1-ol hydrochloride

: 1421014-04-1
(1S,2S)-1-chloro-1-(4-fluorophenyl)-3-methylbutan-2-amine hydrochloride

: 1421014-07-4
(1R,2S)-1-chloro-1-(4-fluorophenyl)-3-methylbutan-2-amine hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 10 wt% Pd(OH)2 on carbon; hydrogen / methanol / 24 h / 20 °C

2: thionyl chloride / toluene / 15 h / 0 - 40 °C

With thionyl chloride; 10 wt% Pd(OH)2 on carbon; hydrogen; In methanol; toluene;
DOI:10.1016/j.tetlet.2012.11.079