(1R,cis)-N-tosyl-3-aminomethyl-1,2,2-trimethylcyclopentylmethanol

Base Information

• Chemical Name: (1R,cis)-N-tosyl-3-aminomethyl-1,2,2-trimethylcyclopentylmethanol
• CAS No.: 156660-30-9
• Molecular Formula: C₁₇H₂₇NO₃S
• Molecular Weight: 325.472
• Mol file: 156660-30-9.mol

Synonyms:(1R,cis)-N-tosyl-3-aminomethyl-1,2,2-trimethylcyclopentylmethanol

Chemical Property of (1R,cis)-N-tosyl-3-aminomethyl-1,2,2-trimethylcyclopentylmethanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,cis)-N-tosyl-3-aminomethyl-1,2,2-trimethylcyclopentylmethanol

There total 3 articles about (1R,cis)-N-tosyl-3-aminomethyl-1,2,2-trimethylcyclopentylmethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

(1R)-N-tosyl-1,8,8-trimethyl-3-azabicyclo<3.2.1>octan-2-one (156660-29-6) → (1R,cis)-N-tosyl-3-aminomethyl-1,2,2-trimethylcyclopentylmethanol (156660-30-9)

Guidance literature:

With lithium borohydride; In tetrahydrofuran; for 18h; Heating;

DOI:10.1016/S0040-4020(01)85077-8

Reference yield:

(1R,4R)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-one (464-49-3,68546-28-1) → (1R,cis)-N-tosyl-3-aminomethyl-1,2,2-trimethylcyclopentylmethanol (156660-30-9)

Guidance literature:

Multi-step reaction with 3 steps

1: H₂N-O-SO₃H / acetic acid / 8 h / Heating

2: 60 percent / 1.) NaH / tetrahydrofuran; paraffin / 1.) r.t., 1 h; 2.) r.t., overnight

3: 82 percent / LiBH₄ / tetrahydrofuran / 18 h / Heating

With lithium borohydride; sodium hydride; hydroxylamine-O-sulfonic acid; In tetrahydrofuran; acetic acid; paraffin;

DOI:10.1016/S0040-4020(01)85077-8

Reference yield:

(1R)-1,8,8-trimethyl-3-azabicyclo<3.2.1>octan-2-one (107133-28-8) → (1R,cis)-N-tosyl-3-aminomethyl-1,2,2-trimethylcyclopentylmethanol (156660-30-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 60 percent / 1.) NaH / tetrahydrofuran; paraffin / 1.) r.t., 1 h; 2.) r.t., overnight

2: 82 percent / LiBH₄ / tetrahydrofuran / 18 h / Heating

With lithium borohydride; sodium hydride; In tetrahydrofuran; paraffin;

DOI:10.1016/S0040-4020(01)85077-8

upstream raw materials:

(1R)-N-tosyl-1,8,8-trimethyl-3-azabicyclo<3.2.1>octan-2-one

(1R,4R)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-one

(1R)-1,8,8-trimethyl-3-azabicyclo<3.2.1>octan-2-one