Technology Process of (-)-(3E,7E,11E)-13-(tert-Butyldiphenylsiloxyl)neocembrene
There total 12 articles about (-)-(3E,7E,11E)-13-(tert-Butyldiphenylsiloxyl)neocembrene which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
pyridine; titanium tetrachloride; zinc;
In
1,2-dimethoxyethane;
for 2h;
Heating;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 80 percent / Ph3P; NCS / tetrahydrofuran / 12 h / 23 °C
2.1: 76 percent / NaHCO3 / toluene / 24 h
3.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C
3.2: tetrahydrofuran; hexane / 4.5 h / -78 - 23 °C
3.3: 618 mg / Na(Hg); Na2HPO4 / methanol / 6 h / 23 °C
4.1: 89 percent / p-TsOH / acetone / 4 h / 40 °C
5.1: 81 percent / TiCl4; Zn; pyridine / 1,2-dimethoxy-ethane / 2 h / Heating
With
pyridine; N-chloro-succinimide; n-butyllithium; titanium tetrachloride; sodium hydrogencarbonate; toluene-4-sulfonic acid; triphenylphosphine; zinc;
In
tetrahydrofuran; 1,2-dimethoxyethane; hexane; acetone; toluene;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: 60 percent / SeO2; t-BuOOH / CH2Cl2 / 3 h / 23 °C
2.1: 92 percent / oxalic acid / benzene / 6 h / Heating
3.1: 80 percent / Ph3P; NCS / tetrahydrofuran / 12 h / 23 °C
4.1: 76 percent / NaHCO3 / toluene / 24 h
5.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C
5.2: tetrahydrofuran; hexane / 4.5 h / -78 - 23 °C
5.3: 618 mg / Na(Hg); Na2HPO4 / methanol / 6 h / 23 °C
6.1: 89 percent / p-TsOH / acetone / 4 h / 40 °C
7.1: 81 percent / TiCl4; Zn; pyridine / 1,2-dimethoxy-ethane / 2 h / Heating
With
pyridine; tert.-butylhydroperoxide; N-chloro-succinimide; n-butyllithium; selenium(IV) oxide; oxalic acid; titanium tetrachloride; sodium hydrogencarbonate; toluene-4-sulfonic acid; triphenylphosphine; zinc;
In
tetrahydrofuran; 1,2-dimethoxyethane; hexane; dichloromethane; acetone; toluene; benzene;
