(3S,3aS,7aR)-3-((1S,2R,5S)-2-Isopropyl-5-methyl-cyclohexyloxy)-3a,7a-dihydro-3H,4H-isobenzofuran-1,5-dione

Base Information

Chemical Name:(3S,3aS,7aR)-3-((1S,2R,5S)-2-Isopropyl-5-methyl-cyclohexyloxy)-3a,7a-dihydro-3H,4H-isobenzofuran-1,5-dione
CAS No.:287934-58-1
Molecular Formula:C₁₈H₂₆O₄
Molecular Weight:306.402
Hs Code.:

Synonyms:(3S,3aS,7aR)-3-((1S,2R,5S)-2-Isopropyl-5-methyl-cyclohexyloxy)-3a,7a-dihydro-3H,4H-isobenzofuran-1,5-dione

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Chemical Property of (3S,3aS,7aR)-3-((1S,2R,5S)-2-Isopropyl-5-methyl-cyclohexyloxy)-3a,7a-dihydro-3H,4H-isobenzofuran-1,5-dione

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Technology Process of (3S,3aS,7aR)-3-((1S,2R,5S)-2-Isopropyl-5-methyl-cyclohexyloxy)-3a,7a-dihydro-3H,4H-isobenzofuran-1,5-dione

There total 1 articles about (3S,3aS,7aR)-3-((1S,2R,5S)-2-Isopropyl-5-methyl-cyclohexyloxy)-3a,7a-dihydro-3H,4H-isobenzofuran-1,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 54125-02-9
danishefsky's diene

: 122079-41-8
(5S)-(D-menthyloxy)-2(5H)-furanone

: 287934-58-1
(3S,3aS,7aR)-3-((1S,2R,5S)-2-Isopropyl-5-methyl-cyclohexyloxy)-3a,7a-dihydro-3H,4H-isobenzofuran-1,5-dione

Guidance literature:: danishefsky's diene; (5S)-(D-menthyloxy)-2(5H)-furanone; In toluene; Heating;

With pyridine; trimethylsilyl trifluoromethanesulfonate; In dichloromethane; at -78 ℃;
DOI:10.1021/ja011285y

Reference yield:

: 287934-58-1
(3S,3aS,7aR)-3-((1S,2R,5S)-2-Isopropyl-5-methyl-cyclohexyloxy)-3a,7a-dihydro-3H,4H-isobenzofuran-1,5-dione

: 287934-60-5
(3S,3aS,5R,7aR)-5-Hydroxy-3-((1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyloxy)-3a,4,5,7a-tetrahydro-3H-isobenzofuran-1-one

Guidance literature:: With sodium tetrahydroborate; cerium(III) chloride; In methanol; at -78 ℃;
DOI:10.1021/ja011285y

Reference yield:

: 287934-58-1
(3S,3aS,7aR)-3-((1S,2R,5S)-2-Isopropyl-5-methyl-cyclohexyloxy)-3a,7a-dihydro-3H,4H-isobenzofuran-1,5-dione

: 198191-76-3
(3R,3aS,5R,7aR)-3-Allyl-5-(tert-butyl-diphenyl-silanyloxy)-3a,4,5,7a-tetrahydro-3H-isobenzofuran-1-one

Guidance literature:: Multi-step reaction with 4 steps

1: NaBH₄; CeCl₃ / methanol / -78 °C

2: 100 percent / imid. / dimethylformamide

3: 81 percent / aq. Py*CSA / acetonitrile / 80 °C

4: aq. Bu₄NBr / tetrahydrofuran

With 1H-imidazole; sodium tetrahydroborate; cerium(III) chloride; Py*CSA; tetrabutylammomium bromide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ja011285y