(-)-(7S)-3,6,6-trimethyl-1-phenyl-7-(4-phenyl-[1,2,3]triazol-1-yl)-4,5,6,7-tetrahydro-1H-indazol-4-one

Base Information

• Chemical Name: (-)-(7S)-3,6,6-trimethyl-1-phenyl-7-(4-phenyl-[1,2,3]triazol-1-yl)-4,5,6,7-tetrahydro-1H-indazol-4-one
• CAS No.: 1315509-63-7
• Molecular Formula: C₂₄H₂₃N₅O
• Molecular Weight: 397.48
• Mol file: 1315509-63-7.mol

Synonyms:(-)-(7S)-3,6,6-trimethyl-1-phenyl-7-(4-phenyl-[1,2,3]triazol-1-yl)-4,5,6,7-tetrahydro-1H-indazol-4-one

Chemical Property of (-)-(7S)-3,6,6-trimethyl-1-phenyl-7-(4-phenyl-[1,2,3]triazol-1-yl)-4,5,6,7-tetrahydro-1H-indazol-4-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (-)-(7S)-3,6,6-trimethyl-1-phenyl-7-(4-phenyl-[1,2,3]triazol-1-yl)-4,5,6,7-tetrahydro-1H-indazol-4-one

There total 4 articles about (-)-(7S)-3,6,6-trimethyl-1-phenyl-7-(4-phenyl-[1,2,3]triazol-1-yl)-4,5,6,7-tetrahydro-1H-indazol-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

(-)-(7S)-7-azido-3,6,6-trimethyl-1-phenyl-4,5,6,7-tetrahydro-1H-indazol-4-one (1315509-57-9) + phenylacetylene (536-74-3) → (-)-(7S)-3,6,6-trimethyl-1-phenyl-7-(4-phenyl-[1,2,3]triazol-1-yl)-4,5,6,7-tetrahydro-1H-indazol-4-one (1315509-63-7)

Guidance literature:

With copper; copper(II) sulfate; In water; iso-butanol; at 40 ℃; for 8h;

DOI:10.1016/j.tetasy.2011.03.010

Reference yield:

(+)-(7S)-7-amino-3,6,6-trimethyl-1-phenyl-4,5,6,7-tetrahydro-1H-indazol-4-one (1315509-50-2) → (-)-(7S)-3,6,6-trimethyl-1-phenyl-7-(4-phenyl-[1,2,3]triazol-1-yl)-4,5,6,7-tetrahydro-1H-indazol-4-one (1315509-63-7)

Guidance literature:

Multi-step reaction with 2 steps

1: triflic azide; sodium hydrogencarbonate; copper(II) sulfate / methanol; dichloromethane; water / 24 h / 20 °C

2: copper; copper(II) sulfate / water; iso-butanol / 8 h / 40 °C

With triflic azide; copper; sodium hydrogencarbonate; copper(II) sulfate; In methanol; dichloromethane; water; iso-butanol; 2: Huisgen cycloaddition;

DOI:10.1016/j.tetasy.2011.03.010

Reference yield:

(7S)-3,6,6-trimethyl-4-oxo-1-phenyl-4,5,6,7-tetrahydro-1H-indazol-7-yl-ammonium (2S,3S)-2,3-bis-benzoyloxy-3-carboxy-propionate (1315509-52-4) → (-)-(7S)-3,6,6-trimethyl-1-phenyl-7-(4-phenyl-[1,2,3]triazol-1-yl)-4,5,6,7-tetrahydro-1H-indazol-4-one (1315509-63-7)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / chloroform; water / 0.5 h

2: triflic azide; sodium hydrogencarbonate; copper(II) sulfate / methanol; dichloromethane; water / 24 h / 20 °C

3: copper; copper(II) sulfate / water; iso-butanol / 8 h / 40 °C

With triflic azide; copper; sodium hydrogencarbonate; potassium carbonate; copper(II) sulfate; In methanol; dichloromethane; chloroform; water; iso-butanol; 3: Huisgen cycloaddition;

DOI:10.1016/j.tetasy.2011.03.010

upstream raw materials:

(+)-(7S)-7-amino-3,6,6-trimethyl-1-phenyl-4,5,6,7-tetrahydro-1H-indazol-4-one

(7S)-3,6,6-trimethyl-4-oxo-1-phenyl-4,5,6,7-tetrahydro-1H-indazol-7-yl-ammonium (2S,3S)-2,3-bis-benzoyloxy-3-carboxy-propionate

(-)-(7S)-7-azido-3,6,6-trimethyl-1-phenyl-4,5,6,7-tetrahydro-1H-indazol-4-one

phenylacetylene