2-Thiazolecarboxylic acid, 4-[4-(trifluoromethyl)phenyl]-

Base Information

Chemical Name:2-Thiazolecarboxylic acid, 4-[4-(trifluoromethyl)phenyl]-
CAS No.:886366-98-9
Molecular Formula:C₁₁H₆F₃NO₂S
Molecular Weight:273.235
Hs Code.:
DSSTox Substance ID:DTXSID00695339
Wikidata:Q82624491
Mol file:886366-98-9.mol

Synonyms:886366-98-9;2-Thiazolecarboxylic acid, 4-[4-(trifluoromethyl)phenyl]-;4-(4-(trifluoromethyl)phenyl)thiazole-2-carboxylic acid;4-[4-(Trifluoromethyl)phenyl]-1,3-thiazole-2-carboxylic acid;2-Thiazolecarboxylicacid, 4-[4-(trifluoromethyl)phenyl]-;4-[4-(trifluoromethyl)phenyl]-2-Thiazolecarboxylic acid;4-(4-TRIFLUOROMETHYL-PHENYL)-THIAZOLE-2-CARBOXYLIC ACID;4-(4-(trifluoromethyl)phenyl)-2-thiazolecarboxylic acid;SCHEMBL4528732;DTXSID00695339;MFCD07375213;AKOS015852905;AB41437;FT-0709205;4-(4-(trifluoromethyl)phenyl)thiazole-2-carboxylicacid

Suppliers and Price of 2-Thiazolecarboxylic acid, 4-[4-(trifluoromethyl)phenyl]-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
4-(4-(Trifluoromethyl)phenyl)thiazole-2-carboxylicacid 97%
5g
$ 885.00

American Custom Chemicals Corporation
4-(4-TRIFLUOROMETHYL-PHENYL)-THIAZOLE-2-CARBOXYLIC ACID 95.00%
5MG
$ 505.59

Alichem
4-(4-(Trifluoromethyl)phenyl)thiazole-2-carboxylicacid
5g
$ 946.95

Total 8 raw suppliers

Chemical Property of 2-Thiazolecarboxylic acid, 4-[4-(trifluoromethyl)phenyl]-

Chemical Property:

PSA：78.43000
LogP:3.52710
XLogP3:3.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:2
Exact Mass:273.00713409
Heavy Atom Count:18
Complexity:316

Purity/Quality:

97% ^*data from raw suppliers

4-(4-(Trifluoromethyl)phenyl)thiazole-2-carboxylicacid 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=CC=C1C2=CSC(=N2)C(=O)O)C(F)(F)F

Technology Process of 2-Thiazolecarboxylic acid, 4-[4-(trifluoromethyl)phenyl]-

There total 2 articles about 2-Thiazolecarboxylic acid, 4-[4-(trifluoromethyl)phenyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 886366-40-1
ethyl 4-(p-tolyl)thiazole-2-carboxylate

: 886366-98-9
4-(4-(trifluoromethyl)phenyl)thiazole-2-carboxylic acid

Guidance literature:: ethyl 4-(p-tolyl)thiazole-2-carboxylate; With lithium hydroxide; water; In tetrahydrofuran; for 2h; Heating / reflux;

With hydrogenchloride; water; In tetrahydrofuran;

Reference yield:

: 383-53-9
2-bromo-1-[4-(trifluoromethyl)phenyl]ethanone

: 886366-98-9
4-(4-(trifluoromethyl)phenyl)thiazole-2-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: ethanol / Reflux

2: sodium hydroxide; water / ethanol / 20 °C

With water; sodium hydroxide; In ethanol;
DOI:10.1016/j.bmcl.2012.09.099