5-(2-dimethylamino-pyrimidin-5-yl)-1-(2-fluoro-phenyl)-4-formyl-1H-pyrazole-3-carboxylic acid cyclohexylamide

Base Information

• Chemical Name: 5-(2-dimethylamino-pyrimidin-5-yl)-1-(2-fluoro-phenyl)-4-formyl-1H-pyrazole-3-carboxylic acid cyclohexylamide
• CAS No.: 1034303-40-6
• Molecular Formula: C₂₃H₂₅FN₆O₂
• Molecular Weight: 436.489
• Mol file: 1034303-40-6.mol

Synonyms:5-(2-dimethylamino-pyrimidin-5-yl)-1-(2-fluoro-phenyl)-4-formyl-1H-pyrazole-3-carboxylic acid cyclohexylamide

Chemical Property of 5-(2-dimethylamino-pyrimidin-5-yl)-1-(2-fluoro-phenyl)-4-formyl-1H-pyrazole-3-carboxylic acid cyclohexylamide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 5-(2-dimethylamino-pyrimidin-5-yl)-1-(2-fluoro-phenyl)-4-formyl-1H-pyrazole-3-carboxylic acid cyclohexylamide

There total 1 articles about 5-(2-dimethylamino-pyrimidin-5-yl)-1-(2-fluoro-phenyl)-4-formyl-1H-pyrazole-3-carboxylic acid cyclohexylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

N,N-dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine-2-amine (1032759-30-0) + 5-chloro-1-(2-fluoro-phenyl)-4-formyl-1H-pyrazole-3-carboxylic acid cyclohexylamide (1034303-30-4) → 5-(2-dimethylamino-pyrimidin-5-yl)-1-(2-fluoro-phenyl)-4-formyl-1H-pyrazole-3-carboxylic acid cyclohexylamide (1034303-40-6)

Guidance literature:

With potassium carbonate; [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl) palladium(II) dichloride; In 1,4-dioxane; at 60 ℃; for 16h;

Reference yield:

5-(2-dimethylamino-pyrimidin-5-yl)-1-(2-fluoro-phenyl)-4-formyl-1H-pyrazole-3-carboxylic acid cyclohexylamide (1034303-40-6) → 5-(2-dimethylamino-pyrimidin-5-yl)-1-(2-fluoro-phenyl)-4-hydroxymethyl-1H-pyrazole-3-carboxylic acid cyclohexylamide

Guidance literature:

5-(2-dimethylamino-pyrimidin-5-yl)-1-(2-fluoro-phenyl)-4-formyl-1H-pyrazole-3-carboxylic acid cyclohexylamide; With sodium tetrahydroborate; In acetonitrile; for 3h;

With hydrogenchloride; water; In acetonitrile;

upstream raw materials:

N,N-dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine-2-amine

5-chloro-1-(2-fluoro-phenyl)-4-formyl-1H-pyrazole-3-carboxylic acid cyclohexylamide