(4R,6R)-6-ethoxy-4-phenyl-5,6-dihydro-4H-pyran-2-carboxylic acid ethyl ester

Base Information

Chemical Name:(4R,6R)-6-ethoxy-4-phenyl-5,6-dihydro-4H-pyran-2-carboxylic acid ethyl ester
CAS No.:220740-99-8
Molecular Formula:C₁₆H₂₀O₄
Molecular Weight:276.332
Hs Code.:

Synonyms:(4R,6R)-6-ethoxy-4-phenyl-5,6-dihydro-4H-pyran-2-carboxylic acid ethyl ester

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Chemical Property of (4R,6R)-6-ethoxy-4-phenyl-5,6-dihydro-4H-pyran-2-carboxylic acid ethyl ester

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Technology Process of (4R,6R)-6-ethoxy-4-phenyl-5,6-dihydro-4H-pyran-2-carboxylic acid ethyl ester

There total 5 articles about (4R,6R)-6-ethoxy-4-phenyl-5,6-dihydro-4H-pyran-2-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 17451-20-6,55674-14-1,55629-96-4
(E)-ethyl-2-oxo-4-phenylbut-3-enoate

: 109-92-2,25104-37-4
ethyl vinyl ether

: 220740-99-8
(4R,6R)-6-ethoxy-4-phenyl-5,6-dihydro-4H-pyran-2-carboxylic acid ethyl ester

Guidance literature:: With florisil; 3 A molecular sieve; [Cu((S,S)-t-Bu-box)(H₂O)2](OTf)2; In hexane; at 0 ℃; for 0.25h;
DOI:10.1002/(SICI)1521-3773(19981231)37:24<3372::AID-ANIE3372>3.0.CO;2-K

Reference yield: 89.0%

: 55629-96-4,55674-14-1,17451-20-6
ethyl 4-phenyl-2-oxobut-3-enoate

: 109-92-2,25104-37-4
ethyl vinyl ether

: 220740-99-8
(4R,6R)-6-ethoxy-4-phenyl-5,6-dihydro-4H-pyran-2-carboxylic acid ethyl ester

Guidance literature:: With C₁₈H₃₅CuF₂N₂O₇S⁽¹⁺⁾*CF₃O₃S^(1-); In tetrahydrofuran; at 0 ℃; for 14h; stereoselective reaction; Molecular sieve;
DOI:10.1039/c5ob00503e

Reference yield:

: 17451-20-6,55674-14-1,55629-96-4
(E)-ethyl-2-oxo-4-phenylbut-3-enoate

: 109-92-2,25104-37-4
ethyl vinyl ether

: 220740-99-8
(4R,6R)-6-ethoxy-4-phenyl-5,6-dihydro-4H-pyran-2-carboxylic acid ethyl ester

: ethyl 2-ethoxy-3,4-dihydro-4-phenyl-2H-pyran-6-carboxylate

Guidance literature:: With 3 A molecular sieve; [Cu((S,S)-t-Bu-box)(H₂O)2](OTf)2; In tetrahydrofuran; at 0 ℃; for 0.25h; Yield given; Yields of byproduct given. Title compound not separated from byproducts;
DOI:10.1002/(SICI)1521-3773(19981231)37:24<3372::AID-ANIE3372>3.0.CO;2-K