(2R,3R,4R,5S,7S)-7-(tert-butyldimethylsilanyloxy)-2,3-dihydroxy-4-methyl-5-triisopropylsilanyloxycycloheptanone

Base Information

• Chemical Name: (2R,3R,4R,5S,7S)-7-(tert-butyldimethylsilanyloxy)-2,3-dihydroxy-4-methyl-5-triisopropylsilanyloxycycloheptanone
• CAS No.: 606128-77-2
• Molecular Formula: C₂₃H₄₈O₅Si₂
• Molecular Weight: 460.802
• Mol file: 606128-77-2.mol

Synonyms:(2R,3R,4R,5S,7S)-7-(tert-butyldimethylsilanyloxy)-2,3-dihydroxy-4-methyl-5-triisopropylsilanyloxycycloheptanone

Chemical Property of (2R,3R,4R,5S,7S)-7-(tert-butyldimethylsilanyloxy)-2,3-dihydroxy-4-methyl-5-triisopropylsilanyloxycycloheptanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R,3R,4R,5S,7S)-7-(tert-butyldimethylsilanyloxy)-2,3-dihydroxy-4-methyl-5-triisopropylsilanyloxycycloheptanone

There total 1 articles about (2R,3R,4R,5S,7S)-7-(tert-butyldimethylsilanyloxy)-2,3-dihydroxy-4-methyl-5-triisopropylsilanyloxycycloheptanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

triisopropylsilyl trifluoromethanesulfonate (80522-42-5) → (2R,3R,4R,5S,7S)-7-(tert-butyldimethylsilanyloxy)-2,3-dihydroxy-4-methyl-5-triisopropylsilanyloxycycloheptanone (606128-77-2)

Guidance literature:

Multi-step reaction with 4 steps

1: (C₂H₅)3N / CH₂Cl₂ / 1 h / 20 °C

2: O₂; 5,10,15,20-tetraphenyl-21H,23H-porphine / CH₂Cl₂ / 0.5 h / -78 °C / Irradiation

3: dimethyl dioxirane / CH₂Cl₂ / 2 h / 0 °C

4: H₂; NaHCO₃ / Pd/C / methanol / 0.33 h / 20 °C

With hydrogen; oxygen; 3,3-dimethyldioxirane; 5,15,10,20-tetraphenylporphyrin; sodium hydrogencarbonate; triethylamine; palladium on activated charcoal; In methanol; dichloromethane;

DOI:10.1002/anie.200350955

upstream raw materials:

triisopropylsilyl trifluoromethanesulfonate