benzhydryl biphenyl-4-carboxylate

Base Information

• Chemical Name: benzhydryl biphenyl-4-carboxylate
• CAS No.: 66365-92-2
• Molecular Formula: C₂₆H₂₀O₂
• Molecular Weight: 364.444
• Mol file: 66365-92-2.mol

Synonyms:benzhydryl biphenyl-4-carboxylate

Chemical Property of benzhydryl biphenyl-4-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of benzhydryl biphenyl-4-carboxylate

There total 4 articles about benzhydryl biphenyl-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

2-(diphenylmethoxy)-pyridine + biphenyl-4-carboxylic acid (92-92-2) → benzhydryl biphenyl-4-carboxylate (66365-92-2)

Guidance literature:

With boron trifluoride diethyl etherate; In 1,2-dichloro-ethane; at 20 ℃; for 6h; Inert atmosphere;

DOI:10.1016/j.tetlet.2018.04.002

Reference yield:

1,1-Diphenylmethanol (91-01-0) → benzhydryl biphenyl-4-carboxylate (66365-92-2)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium hydroxide; 18-crown-6 ether / toluene / 5 h / 110 °C / Inert atmosphere

2: boron trifluoride diethyl etherate / 1,2-dichloro-ethane / 6 h / 20 °C / Inert atmosphere

With 18-crown-6 ether; boron trifluoride diethyl etherate; potassium hydroxide; In 1,2-dichloro-ethane; toluene;

DOI:10.1016/j.tetlet.2018.04.002

Reference yield:

diazodiphenylmethane (908093-98-1) + biphenyl-4-carboxylic acid (92-92-2) → benzhydryl biphenyl-4-carboxylate (66365-92-2)

Guidance literature:

In 2-methoxy-ethanol; at 30 ℃; Rate constant;

upstream raw materials:

diazodiphenylmethane

biphenyl-4-carboxylic acid

1,1-Diphenylmethanol

4-biphenyl-carboxylic acid chloride

Downstream raw materials:

Benzhydryl-4-biphenyl-keton