3-(5-chloro-2-fluoropyridin-4-yl)-5-fluoro-N-((tetrahydro-2H-pyran-4-yl)methyl)aniline

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Chemical Name:3-(5-chloro-2-fluoropyridin-4-yl)-5-fluoro-N-((tetrahydro-2H-pyran-4-yl)methyl)aniline
CAS No.:1269815-45-3
Molecular Formula:C₁₇H₁₇ClF₂N₂O
Molecular Weight:338.785
Hs Code.:

Synonyms:3-(5-chloro-2-fluoropyridin-4-yl)-5-fluoro-N-((tetrahydro-2H-pyran-4-yl)methyl)aniline

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Chemical Property of 3-(5-chloro-2-fluoropyridin-4-yl)-5-fluoro-N-((tetrahydro-2H-pyran-4-yl)methyl)aniline

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Technology Process of 3-(5-chloro-2-fluoropyridin-4-yl)-5-fluoro-N-((tetrahydro-2H-pyran-4-yl)methyl)aniline

There total 4 articles about 3-(5-chloro-2-fluoropyridin-4-yl)-5-fluoro-N-((tetrahydro-2H-pyran-4-yl)methyl)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1034659-38-5
(5-chloro-2-fluoropyridine-4-yl)boronic acid

: 1269815-44-2
3-bromo-5-fluoro-N-((tetrahydro-2H-pyran-4-yl)methyl)aniline

: 1269815-45-3
3-(5-chloro-2-fluoropyridin-4-yl)-5-fluoro-N-((tetrahydro-2H-pyran-4-yl)methyl)aniline

Guidance literature:: With sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,2-dimethoxyethane; water; at 103 ℃; for 2h;

Reference yield:

: 389621-78-7
(tetrahydro-2H-pyran-4-yl)methanamine hydrochloride

: 1269815-45-3
3-(5-chloro-2-fluoropyridin-4-yl)-5-fluoro-N-((tetrahydro-2H-pyran-4-yl)methyl)aniline

Guidance literature:: Multi-step reaction with 2 steps

1: potassium tert-butylate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / palladium diacetate / 1,4-dioxane / 18 h / 93 °C

2: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane; water / 2 h / 103 °C

With potassium tert-butylate; sodium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium diacetate; In 1,4-dioxane; 1,2-dimethoxyethane; water;

Reference yield:

: 1435-51-4
1,3-dibromo-5-fluorobenzene

: 1269815-45-3
3-(5-chloro-2-fluoropyridin-4-yl)-5-fluoro-N-((tetrahydro-2H-pyran-4-yl)methyl)aniline

Guidance literature:: Multi-step reaction with 2 steps

1: potassium tert-butylate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / palladium diacetate / 1,4-dioxane / 18 h / 93 °C

2: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane; water / 2 h / 103 °C

With potassium tert-butylate; sodium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium diacetate; In 1,4-dioxane; 1,2-dimethoxyethane; water;