2-(5,7-dioxo-5,7-dihydro-pyrrolo[3,4-b]pyridin-6-yl)-N-methyl-N-phenyl-acetamide

Base Information

• Chemical Name: 2-(5,7-dioxo-5,7-dihydro-pyrrolo[3,4-b]pyridin-6-yl)-N-methyl-N-phenyl-acetamide
• CAS No.: 860299-07-6
• Molecular Formula: C₁₆H₁₃N₃O₃
• Molecular Weight: 295.298

Synonyms:2-(5,7-dioxo-5,7-dihydro-pyrrolo[3,4-b]pyridin-6-yl)-N-methyl-N-phenyl-acetamide

Chemical Property of 2-(5,7-dioxo-5,7-dihydro-pyrrolo[3,4-b]pyridin-6-yl)-N-methyl-N-phenyl-acetamide

Chemical Property:

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Technology Process of 2-(5,7-dioxo-5,7-dihydro-pyrrolo[3,4-b]pyridin-6-yl)-N-methyl-N-phenyl-acetamide

There total 3 articles about 2-(5,7-dioxo-5,7-dihydro-pyrrolo[3,4-b]pyridin-6-yl)-N-methyl-N-phenyl-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

2,3-pyridinedicarboximide (4664-00-0,303983-78-0) + N-methyl-2-chloroacetanilide (2620-05-5) → 2-(5,7-dioxo-5,7-dihydro-pyrrolo[3,4-b]pyridin-6-yl)-N-methyl-N-phenyl-acetamide (860299-07-6)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 50 ℃; for 3h; Molecular sieve;

DOI:10.1055/s-0030-1258398

Reference yield: 60.0%

(5,7-dioxo-5,7-dihydro-pyrrolo[3,4-b]pyridin-6-yl)-acetyl chloride (877879-78-2) + N-methylaniline (100-61-8) → 2-(5,7-dioxo-5,7-dihydro-pyrrolo[3,4-b]pyridin-6-yl)-N-methyl-N-phenyl-acetamide (860299-07-6)

Guidance literature:

With sodium hydroxide; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1002/jhet.5570420404

Reference yield:

2,3-pyridinedicarboximidoacetic acid (36239-67-5) → 2-(5,7-dioxo-5,7-dihydro-pyrrolo[3,4-b]pyridin-6-yl)-N-methyl-N-phenyl-acetamide (860299-07-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / (COCl)2 / benzene / 5 h / 40 °C

2: 60 percent / aq. NaOH / CH₂Cl₂ / 1 h / 20 °C

With sodium hydroxide; oxalyl dichloride; In dichloromethane; benzene;

DOI:10.1002/jhet.5570420404

upstream raw materials:

(5,7-dioxo-5,7-dihydro-pyrrolo[3,4-b]pyridin-6-yl)-acetyl chloride

N-methylaniline

2,3-pyridinedicarboximidoacetic acid

2,3-pyridinedicarboximide

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