{3-[4-(tert-butyl-diphenyl-silanyloxy)-butyl]-phenyl}-pyridin-3-yl-methanone

Base Information

Chemical Name:{3-[4-(tert-butyl-diphenyl-silanyloxy)-butyl]-phenyl}-pyridin-3-yl-methanone
CAS No.:476686-88-1
Molecular Formula:C₃₂H₃₅NO₂Si
Molecular Weight:493.721
Hs Code.:

{3-[4-(<i>tert</i>-butyl-diphenyl-silanyloxy)-butyl]-phenyl}-pyridin-3-yl-methanone

Synonyms:{3-[4-(tert-butyl-diphenyl-silanyloxy)-butyl]-phenyl}-pyridin-3-yl-methanone

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Chemical Property of {3-[4-(tert-butyl-diphenyl-silanyloxy)-butyl]-phenyl}-pyridin-3-yl-methanone

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Technology Process of {3-[4-(tert-butyl-diphenyl-silanyloxy)-butyl]-phenyl}-pyridin-3-yl-methanone

There total 8 articles about {3-[4-(tert-butyl-diphenyl-silanyloxy)-butyl]-phenyl}-pyridin-3-yl-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 477231-12-2
{3-[4-(tert-butyl-diphenyl-silanyloxy)-butyl]-phenyl}-pyridin-3-yl-methanol

: 476686-88-1
{3-[4-(tert-butyl-diphenyl-silanyloxy)-butyl]-phenyl}-pyridin-3-yl-methanone

Guidance literature:: With manganese(IV) oxide; In dichloromethane; Heating;
DOI:10.1016/S0960-894X(02)00005-7

Reference yield:

: 500-22-1
3-pyridinecarboxaldehyde

: 476686-88-1
{3-[4-(tert-butyl-diphenyl-silanyloxy)-butyl]-phenyl}-pyridin-3-yl-methanone

Guidance literature:: Multi-step reaction with 3 steps

1: 62 percent / nBuLi / tetrahydrofuran / -78 °C

2: 65 percent / H₂ / 10 percent Pd-C / acetic acid; methanol

3: 86 percent / MnO₂ / CH₂Cl₂ / Heating

With manganese(IV) oxide; n-butyllithium; hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; acetic acid;
DOI:10.1016/S0960-894X(02)00005-7

Reference yield:

: 51114-94-4
(2-carboxyethyl)triphenylphosphonium bromide

: 476686-88-1
{3-[4-(tert-butyl-diphenyl-silanyloxy)-butyl]-phenyl}-pyridin-3-yl-methanone

Guidance literature:: Multi-step reaction with 7 steps

1: KOtBu / tetrahydrofuran

2: SOCl₂

3: 75 percent / LAH / tetrahydrofuran

4: 100 percent / imidazole / dimethylformamide

5: 62 percent / nBuLi / tetrahydrofuran / -78 °C

6: 65 percent / H₂ / 10 percent Pd-C / acetic acid; methanol

7: 86 percent / MnO₂ / CH₂Cl₂ / Heating

With 1H-imidazole; manganese(IV) oxide; lithium aluminium tetrahydride; n-butyllithium; thionyl chloride; potassium tert-butylate; hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; acetic acid; N,N-dimethyl-formamide; 1: Wittig olefination;
DOI:10.1016/S0960-894X(02)00005-7