1-(4'-fluoro-[1,1'-biphenyl]-4-yl)-1-(1-trityl-1H-imidazol-4-yl)-2-methyl-1-propanol

Base Information

Chemical Name:1-(4'-fluoro-[1,1'-biphenyl]-4-yl)-1-(1-trityl-1H-imidazol-4-yl)-2-methyl-1-propanol
CAS No.:337535-24-7
Molecular Formula:C₃₈H₃₃FN₂O
Molecular Weight:552.691
Hs Code.:

Synonyms:1-(4'-fluoro-[1,1'-biphenyl]-4-yl)-1-(1-trityl-1H-imidazol-4-yl)-2-methyl-1-propanol

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Chemical Property of 1-(4'-fluoro-[1,1'-biphenyl]-4-yl)-1-(1-trityl-1H-imidazol-4-yl)-2-methyl-1-propanol

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Technology Process of 1-(4'-fluoro-[1,1'-biphenyl]-4-yl)-1-(1-trityl-1H-imidazol-4-yl)-2-methyl-1-propanol

There total 4 articles about 1-(4'-fluoro-[1,1'-biphenyl]-4-yl)-1-(1-trityl-1H-imidazol-4-yl)-2-methyl-1-propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 337535-23-6
1-(4-bromophenyl)-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propan-1-ol

: 1765-93-1
4-fluoroboronic acid

: 337535-24-7
1-(4'-fluoro-[1,1'-biphenyl]-4-yl)-1-(1-trityl-1H-imidazol-4-yl)-2-methyl-1-propanol

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,2-dimethoxyethane; water; for 18h; Reflux; Inert atmosphere;
DOI:10.1016/j.bmc.2011.02.009

Reference yield:

: 106-37-6
1.4-dibromobenzene

: 337535-24-7
1-(4'-fluoro-[1,1'-biphenyl]-4-yl)-1-(1-trityl-1H-imidazol-4-yl)-2-methyl-1-propanol

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / diethyl ether / 0.5 h / -78 °C

1.2: 0.5 h / -78 - -50 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,2-dimethoxyethane; water / 18 h / Reflux; Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; sodium carbonate; In 1,2-dimethoxyethane; diethyl ether; water; 2.1: Suzuki coupling;
DOI:10.1016/j.bmc.2011.02.009

Reference yield:

: 2-methyl-1-(1-trityl-1H-imidazol-4-yl)-1-propanone

: 337535-24-7
1-(4'-fluoro-[1,1'-biphenyl]-4-yl)-1-(1-trityl-1H-imidazol-4-yl)-2-methyl-1-propanol

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / diethyl ether / 0.5 h / -78 °C

1.2: 0.5 h / -78 - -50 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,2-dimethoxyethane; water / 18 h / Reflux; Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; sodium carbonate; In 1,2-dimethoxyethane; diethyl ether; water; 2.1: Suzuki coupling;
DOI:10.1016/j.bmc.2011.02.009