5-amino-2-fluoro-4-methyl-N-(2-(4-methylpiperazin-1-yl )benzyl)benzamide

Base Information

Chemical Name:5-amino-2-fluoro-4-methyl-N-(2-(4-methylpiperazin-1-yl )benzyl)benzamide
CAS No.:1426531-72-7
Molecular Formula:C₂₀H₂₅FN₄O
Molecular Weight:356.443
Hs Code.:

Synonyms:5-amino-2-fluoro-4-methyl-N-(2-(4-methylpiperazin-1-yl )benzyl)benzamide

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Chemical Property of 5-amino-2-fluoro-4-methyl-N-(2-(4-methylpiperazin-1-yl )benzyl)benzamide

Chemical Property:

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Technology Process of 5-amino-2-fluoro-4-methyl-N-(2-(4-methylpiperazin-1-yl )benzyl)benzamide

There total 3 articles about 5-amino-2-fluoro-4-methyl-N-(2-(4-methylpiperazin-1-yl )benzyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 655256-68-1
(2-(4-methylpiperazin-1-yl)phenyl)methanamine

: 1263277-38-8
5-amino-2-fluoro-4-methylbenzoic acid

: 1426531-72-7
5-amino-2-fluoro-4-methyl-N-(2-(4-methylpiperazin-1-yl )benzyl)benzamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 25 ℃; for 24h;

Reference yield:

: 753924-40-2
2-fluoro-4-methyl-5-nitrobenzoic acid

: 1426531-72-7
5-amino-2-fluoro-4-methyl-N-(2-(4-methylpiperazin-1-yl )benzyl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: palladium on activated charcoal; ammonium formate / methanol / 2 h / 60 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 24 h / 25 °C

With palladium on activated charcoal; ammonium formate; N-ethyl-N,N-diisopropylamine; HATU; In methanol; N,N-dimethyl-formamide;

Reference yield:

: 7697-23-6
2-fluoro-4-methylbenzoic Acid

: 1426531-72-7
5-amino-2-fluoro-4-methyl-N-(2-(4-methylpiperazin-1-yl )benzyl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: sulfuric acid; nitric acid / 3 h / 0 °C

2: palladium on activated charcoal; ammonium formate / methanol / 2 h / 60 °C / Inert atmosphere

3: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 24 h / 25 °C

With sulfuric acid; palladium on activated charcoal; nitric acid; ammonium formate; N-ethyl-N,N-diisopropylamine; HATU; In methanol; N,N-dimethyl-formamide;