(2R,10R)-N⁴,N⁸-dibenzyl-2,10-dihydroxynorspermine

Base Information

Chemical Name:(2R,10R)-N⁴,N⁸-dibenzyl-2,10-dihydroxynorspermine
CAS No.:259656-78-5
Molecular Formula:C₂₇H₄₄N₄O₂
Molecular Weight:456.672
Hs Code.:

(2R,10R)-N<sup>4</sup>,N<sup>8</sup>-dibenzyl-2,10-dihydroxynorspermine

Synonyms:(2R,10R)-N⁴,N⁸-dibenzyl-2,10-dihydroxynorspermine

Suppliers and Price of (2R,10R)-N⁴,N⁸-dibenzyl-2,10-dihydroxynorspermine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 1 raw suppliers

Chemical Property of (2R,10R)-N⁴,N⁸-dibenzyl-2,10-dihydroxynorspermine

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2R,10R)-N⁴,N⁸-dibenzyl-2,10-dihydroxynorspermine

There total 1 articles about (2R,10R)-N⁴,N⁸-dibenzyl-2,10-dihydroxynorspermine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 259656-76-3
(2S,10S)-N¹,N¹¹-bis(p-toluenesulfonyl)-N⁴,N⁸-dibenzyl-N¹,N¹¹-diethyl-2,10-dihydroxynorspermine

: 259656-78-5
(2R,10R)-N⁴,N⁸-dibenzyl-2,10-dihydroxynorspermine

Guidance literature:: With sodium naphthalenide; In 1,2-dimethoxyethane; at -78 ℃;
DOI:10.1021/jm990375z

Reference yield:

: 259656-78-5
(2R,10R)-N⁴,N⁸-dibenzyl-2,10-dihydroxynorspermine

: 259656-94-5
(2R,10R)-N¹,N¹¹-diethyl-2,10-dihydroxy-N¹,N⁴,N⁸,N¹¹-tetrakis(benzyloxycarbonyl)norspermine

Guidance literature:: Multi-step reaction with 2 steps

1: 82 percent / H₂; 1 N HCl / 10percent Pd/C / ethanol / 22 h / 760.05 Torr

2: 54 percent / aq. KHCO₃ / diethyl ether / 4 h / 20 °C

With hydrogenchloride; hydrogen; potassium hydrogencarbonate; 10percent Pd/C; In diethyl ether; ethanol; 1: debenzylation / 2: Condensation;
DOI:10.1021/jm990375z

Reference yield:

: 259656-78-5
(2R,10R)-N⁴,N⁸-dibenzyl-2,10-dihydroxynorspermine

: (2R,10R)-2,10-bis[(S)-α-methoxy-α-(trifluoromethyl)phenylacetoxy]-N¹,N¹¹-diethyl-N¹,N⁴,N⁸,N¹¹-tetrakis(benzyloxycarbonyl)norspermine

Guidance literature:: Multi-step reaction with 3 steps

1: 82 percent / H₂; 1 N HCl / 10percent Pd/C / ethanol / 22 h / 760.05 Torr

2: 54 percent / aq. KHCO₃ / diethyl ether / 4 h / 20 °C

3: 100 percent / pyridine / CCl₄ / 18 h / 20 °C

With pyridine; hydrogenchloride; hydrogen; potassium hydrogencarbonate; 10percent Pd/C; In tetrachloromethane; diethyl ether; ethanol; 1: debenzylation / 2: Condensation / 3: Acylation;
DOI:10.1021/jm990375z