methyl 7-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)-6-phenylhexanamido)heptanoate

Base Information

Chemical Name:methyl 7-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)-6-phenylhexanamido)heptanoate
CAS No.:1374151-70-8
Molecular Formula:C₃₂H₅₉NO₅Si₂
Molecular Weight:593.995
Hs Code.:

Synonyms:methyl 7-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)-6-phenylhexanamido)heptanoate

Suppliers and Price of methyl 7-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)-6-phenylhexanamido)heptanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of methyl 7-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)-6-phenylhexanamido)heptanoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methyl 7-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)-6-phenylhexanamido)heptanoate

There total 9 articles about methyl 7-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)-6-phenylhexanamido)heptanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₄H₄₄O₄Si₂

: 17994-94-4
methyl 7-aminoheptanoate hydrochloride

: 1374151-70-8
methyl 7-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)-6-phenylhexanamido)heptanoate

Guidance literature:: C₂₄H₄₄O₄Si₂; methyl 7-aminoheptanoate hydrochloride; With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; for 0.0833333h; Inert atmosphere;

With triethylamine; In dichloromethane; at 20 ℃; Inert atmosphere;
DOI:10.1021/ol300707j

Reference yield:

: 1374151-53-7
tert-butyldimethyl((R)-1-((R)-oxiran-2-yl)-3-phenylpropan-2-yloxy)silane

: 1374151-70-8
methyl 7-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)-6-phenylhexanamido)heptanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: copper(l) iodide / tetrahydrofuran / 0.33 h / -78 °C / Inert atmosphere

1.2: -78 - 20 °C / Inert atmosphere

2.1: 1H-imidazole / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

3.1: sodium periodate; potassium permanganate / tert-butyl alcohol / pH 7 / Inert atmosphere; aq. buffer

4.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.08 h / Inert atmosphere

4.2: 20 °C / Inert atmosphere

With 1H-imidazole; dmap; potassium permanganate; sodium periodate; copper(l) iodide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1021/ol300707j

Reference yield:

: (4S,6R)-4,6-bis(tert-butyldimethylsilyloxy)-7-phenylhept-1-ene

: 1374151-70-8
methyl 7-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)-6-phenylhexanamido)heptanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium periodate; potassium permanganate / tert-butyl alcohol / pH 7 / Inert atmosphere; aq. buffer

2.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.08 h / Inert atmosphere

2.2: 20 °C / Inert atmosphere

With dmap; potassium permanganate; sodium periodate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; tert-butyl alcohol;
DOI:10.1021/ol300707j