{(Z)-3-[(R)-8-(2-tert-Butoxycarbonylamino-ethyl)-8-(3,4-dimethoxy-phenyl)-1,4-dioxa-spiro[4.5]dec-6-en-6-yl]-allyl}-carbamic acid tert-butyl ester

Base Information

• Chemical Name: {(Z)-3-[(R)-8-(2-tert-Butoxycarbonylamino-ethyl)-8-(3,4-dimethoxy-phenyl)-1,4-dioxa-spiro[4.5]dec-6-en-6-yl]-allyl}-carbamic acid tert-butyl ester
• CAS No.: 207515-81-9
• Molecular Formula: C₃₁H₄₆N₂O₈
• Molecular Weight: 574.715

Synonyms:{(Z)-3-[(R)-8-(2-tert-Butoxycarbonylamino-ethyl)-8-(3,4-dimethoxy-phenyl)-1,4-dioxa-spiro[4.5]dec-6-en-6-yl]-allyl}-carbamic acid tert-butyl ester

Chemical Property of {(Z)-3-[(R)-8-(2-tert-Butoxycarbonylamino-ethyl)-8-(3,4-dimethoxy-phenyl)-1,4-dioxa-spiro[4.5]dec-6-en-6-yl]-allyl}-carbamic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of {(Z)-3-[(R)-8-(2-tert-Butoxycarbonylamino-ethyl)-8-(3,4-dimethoxy-phenyl)-1,4-dioxa-spiro[4.5]dec-6-en-6-yl]-allyl}-carbamic acid tert-butyl ester

There total 19 articles about {(Z)-3-[(R)-8-(2-tert-Butoxycarbonylamino-ethyl)-8-(3,4-dimethoxy-phenyl)-1,4-dioxa-spiro[4.5]dec-6-en-6-yl]-allyl}-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1S,4R,4aS,8aR)-7-(2-Benzyloxy-ethyl)-4,4a,8,8a-tetrahydro-1H-1,4-methano-naphthalen-5-one (207515-62-6) → {(Z)-3-[(R)-8-(2-tert-Butoxycarbonylamino-ethyl)-8-(3,4-dimethoxy-phenyl)-1,4-dioxa-spiro[4.5]dec-6-en-6-yl]-allyl}-carbamic acid tert-butyl ester (207515-81-9)

Guidance literature:

Multi-step reaction with 19 steps

1: 1.) CuBr*SMe₂, Me₃SiCl, HMPA, 2.) acid / 1.) THF

2: diphenyl ether / 260 °C

3: DIBAL-H, CuI, HMPA / tetrahydrofuran

4: H₂ / 10percent Pd/C

5: imidazole / dimethylformamide

6: 70 percent / t-BuOK / tetrahydrofuran; 2-methyl-propan-2-ol

7: NaBH₄, CeCl₃*7H₂O

8: (CF₃CO₂)IPh

9: NaH / tetrahydrofuran

10: HClO₄, H₂O / tetrahydrofuran

11: 1,2-dichloro-benzene / 180 °C

12: 97 percent / I₂, pyridine / CH₂Cl₂

13: 91 percent / CuI, Et₃N / PdCl₂(PPh₃)2

14: 71 percent / TsOH / benzene

15: 100 percent / Bu₄NF / tetrahydrofuran

16: 90 percent / PPh₃, DIPAD / tetrahydrofuran

17: 86 percent / H₂ / Lindlar catalyst / methanol

18: N₂H₄*H₂O / ethanol / Heating

19: Et₃N / CH₂Cl₂

With pyridine; 1H-imidazole; N,N,N,N,N,N-hexamethylphosphoric triamide; sodium tetrahydroborate; copper(l) iodide; chloro-trimethyl-silane; perchloric acid; cerium(III) chloride; copper(I) bromide dimethylsulfide complex; (CF₃CO₂)IPh; potassium tert-butylate; tetrabutyl ammonium fluoride; water; hydrogen; iodine; sodium hydride; diisobutylaluminium hydride; toluene-4-sulfonic acid; hydrazine hydrate; diisopropyl (E)-azodicarboxylate; triethylamine; triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride; palladium on activated charcoal; Lindlar's catalyst; In tetrahydrofuran; methanol; diphenylether; ethanol; dichloromethane; N,N-dimethyl-formamide; 1,2-dichloro-benzene; tert-butyl alcohol; benzene;

DOI:10.1039/a709212a

Reference yield:

(R)-3-(3,4-Dimethoxy-phenyl)-3-(2-hydroxy-ethyl)-cyclohexanone → {(Z)-3-[(R)-8-(2-tert-Butoxycarbonylamino-ethyl)-8-(3,4-dimethoxy-phenyl)-1,4-dioxa-spiro[4.5]dec-6-en-6-yl]-allyl}-carbamic acid tert-butyl ester (207515-81-9)

Guidance literature:

Multi-step reaction with 15 steps

1: imidazole / dimethylformamide

2: 70 percent / t-BuOK / tetrahydrofuran; 2-methyl-propan-2-ol

3: NaBH₄, CeCl₃*7H₂O

4: (CF₃CO₂)IPh

5: NaH / tetrahydrofuran

6: HClO₄, H₂O / tetrahydrofuran

7: 1,2-dichloro-benzene / 180 °C

8: 97 percent / I₂, pyridine / CH₂Cl₂

9: 91 percent / CuI, Et₃N / PdCl₂(PPh₃)2

10: 71 percent / TsOH / benzene

11: 100 percent / Bu₄NF / tetrahydrofuran

12: 90 percent / PPh₃, DIPAD / tetrahydrofuran

13: 86 percent / H₂ / Lindlar catalyst / methanol

14: N₂H₄*H₂O / ethanol / Heating

15: Et₃N / CH₂Cl₂

With pyridine; 1H-imidazole; sodium tetrahydroborate; copper(l) iodide; perchloric acid; cerium(III) chloride; (CF₃CO₂)IPh; potassium tert-butylate; tetrabutyl ammonium fluoride; water; hydrogen; iodine; sodium hydride; toluene-4-sulfonic acid; hydrazine hydrate; diisopropyl (E)-azodicarboxylate; triethylamine; triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride; Lindlar's catalyst; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; 1,2-dichloro-benzene; tert-butyl alcohol; benzene;

DOI:10.1039/a709212a

Reference yield:

(R)-5-(2-Benzyloxy-ethyl)-5-(3,4-dimethoxy-phenyl)-cyclohex-2-enone (207515-64-8) → {(Z)-3-[(R)-8-(2-tert-Butoxycarbonylamino-ethyl)-8-(3,4-dimethoxy-phenyl)-1,4-dioxa-spiro[4.5]dec-6-en-6-yl]-allyl}-carbamic acid tert-butyl ester (207515-81-9)

Guidance literature:

Multi-step reaction with 17 steps

1: DIBAL-H, CuI, HMPA / tetrahydrofuran

2: H₂ / 10percent Pd/C

3: imidazole / dimethylformamide

4: 70 percent / t-BuOK / tetrahydrofuran; 2-methyl-propan-2-ol

5: NaBH₄, CeCl₃*7H₂O

6: (CF₃CO₂)IPh

7: NaH / tetrahydrofuran

8: HClO₄, H₂O / tetrahydrofuran

9: 1,2-dichloro-benzene / 180 °C

10: 97 percent / I₂, pyridine / CH₂Cl₂

11: 91 percent / CuI, Et₃N / PdCl₂(PPh₃)2

12: 71 percent / TsOH / benzene

13: 100 percent / Bu₄NF / tetrahydrofuran

14: 90 percent / PPh₃, DIPAD / tetrahydrofuran

15: 86 percent / H₂ / Lindlar catalyst / methanol

16: N₂H₄*H₂O / ethanol / Heating

17: Et₃N / CH₂Cl₂

With pyridine; 1H-imidazole; N,N,N,N,N,N-hexamethylphosphoric triamide; sodium tetrahydroborate; copper(l) iodide; perchloric acid; cerium(III) chloride; (CF₃CO₂)IPh; potassium tert-butylate; tetrabutyl ammonium fluoride; water; hydrogen; iodine; sodium hydride; diisobutylaluminium hydride; toluene-4-sulfonic acid; hydrazine hydrate; diisopropyl (E)-azodicarboxylate; triethylamine; triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride; palladium on activated charcoal; Lindlar's catalyst; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; 1,2-dichloro-benzene; tert-butyl alcohol; benzene;

DOI:10.1039/a709212a

upstream raw materials:

di-tert-butyl dicarbonate

(1S,4R,4aS,8aR)-7-(2-Benzyloxy-ethyl)-4,4a,8,8a-tetrahydro-1H-1,4-methano-naphthalen-5-one

(R)-5-(2-Benzyloxy-ethyl)-5-(3,4-dimethoxy-phenyl)-cyclohex-2-enone

(1S,4R,4aS,7R,8aR)-7-(2-Benzyloxy-ethyl)-7-(3,4-dimethoxy-phenyl)-4,4a,6,7,8,8a-hexahydro-1H-1,4-methano-naphthalen-5-one

Downstream raw materials:

(3aS,9bR)-3a-(3,4-Dimethoxy-phenyl)-2,3,3a,4,5,9b-hexahydro-1H-pyrrolo[2,3-f]quinoline

3a-(3,4-dimethoxy-phenyl)-1-methyl-2,3,3a,4,5,9b-hexahydro-1H-pyrrolo[2,3-f]quinoline

(3aS,9bR)-3a-(3,4-Dimethoxy-phenyl)-2,3,3a,4,5,9b-hexahydro-pyrrolo[2,3-f]quinoline-1-carboxylic acid tert-butyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 207515-81-9 {(Z)-3-[(R)-8-(2-tert-Butoxycarbonylamino-ethyl)-8-(3,4-dimethoxy-phenyl)-1,4-dioxa-spiro[4.5]dec-6-en-6-yl]-allyl}-carbamic acid tert-butyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send