(2S)-3-<(S)-2-benzylbutyryl>-2-tert-butyl-1-carbomethoxy-2,3-dihydro-4(1H)-pyrimidinone

Base Information

Chemical Name:(2S)-3-<(S)-2-benzylbutyryl>-2-tert-butyl-1-carbomethoxy-2,3-dihydro-4(1H)-pyrimidinone
CAS No.:138723-65-6
Molecular Formula:C₂₁H₂₈N₂O₄
Molecular Weight:372.464
Hs Code.:

Synonyms:(2S)-3-<(S)-2-benzylbutyryl>-2-tert-butyl-1-carbomethoxy-2,3-dihydro-4(1H)-pyrimidinone

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Chemical Property of (2S)-3-<(S)-2-benzylbutyryl>-2-tert-butyl-1-carbomethoxy-2,3-dihydro-4(1H)-pyrimidinone

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Technology Process of (2S)-3-<(S)-2-benzylbutyryl>-2-tert-butyl-1-carbomethoxy-2,3-dihydro-4(1H)-pyrimidinone

There total 10 articles about (2S)-3-<(S)-2-benzylbutyryl>-2-tert-butyl-1-carbomethoxy-2,3-dihydro-4(1H)-pyrimidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 134772-94-4
(S)-2-tert-butyl-1-carbomethoxy-3-propionyl-2,3-dihydro-4(1H)-pyrimidinone

: 138723-65-6
(2S)-3-<(S)-2-benzylbutyryl>-2-tert-butyl-1-carbomethoxy-2,3-dihydro-4(1H)-pyrimidinone

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) hexamethyldisilylamide / 1.) THF, -78 deg C, 2.5 h, 2.) THF, -23 deg C, 4 h

2: aq. NaOH / methanol / 0.67 h / 4 °C

3: 1.) 30percent aq. H₂O₂, aq. LiOH, 2.) methyl chloroformate / 1.) THF, 30 min, 2.) THF, RT, 4 h

4: 1.) n-BuLi / 1.) THF, -78 deg C, 2 h

5: 1.) hexamethyldisilylamide / 1.) THF, -78 deg C, 2.5 h, 2.) THF, -23 deg C, 4 h

With lithium hydroxide; sodium hydroxide; n-butyllithium; dihydrogen peroxide; hexamethyldisilazide; methyl chloroformate; In methanol;
DOI:10.1021/ja00031a039

Reference yield:

: 138723-62-3
(2S)-2-tert-butyl-1-carbomethoxy-3-<(S)-2-methyl-3-phenylpropionyl>-2,3-dihydro-4(1H)-pyrimidinone

: 138723-65-6
(2S)-3-<(S)-2-benzylbutyryl>-2-tert-butyl-1-carbomethoxy-2,3-dihydro-4(1H)-pyrimidinone

Guidance literature:: Multi-step reaction with 4 steps

1: aq. NaOH / methanol / 0.67 h / 4 °C

2: 1.) 30percent aq. H₂O₂, aq. LiOH, 2.) methyl chloroformate / 1.) THF, 30 min, 2.) THF, RT, 4 h

3: 1.) n-BuLi / 1.) THF, -78 deg C, 2 h

4: 1.) hexamethyldisilylamide / 1.) THF, -78 deg C, 2.5 h, 2.) THF, -23 deg C, 4 h

With lithium hydroxide; sodium hydroxide; n-butyllithium; dihydrogen peroxide; hexamethyldisilazide; methyl chloroformate; In methanol;
DOI:10.1021/ja00031a039

Reference yield:

: 944443-02-1
(S)-2-tert-Butyl-3-(2-methyl-butyryl)-4-oxo-3,4-dihydro-2H-pyrimidine-1-carboxylic acid methyl ester

: 138723-65-6
(2S)-3-<(S)-2-benzylbutyryl>-2-tert-butyl-1-carbomethoxy-2,3-dihydro-4(1H)-pyrimidinone

Guidance literature:: Multi-step reaction with 3 steps

1: 85 percent / 30percent aq. H₂O₂, aq. LiOH / tetrahydrofuran / 0.33 h

2: 1.) n-BuLi / 1.) THF, -78 deg C, 2 h

3: 1.) hexamethyldisilylamide / 1.) THF, -78 deg C, 2.5 h, 2.) THF, -23 deg C, 4 h

With lithium hydroxide; n-butyllithium; dihydrogen peroxide; hexamethyldisilazide; In tetrahydrofuran;
DOI:10.1021/ja00031a039