2-benzyloxycarbonylamino-(1R,2S)-cyclobutane-1-carboxylic acid N-methoxycarbonylethyl amide

Base Information

Chemical Name:2-benzyloxycarbonylamino-(1R,2S)-cyclobutane-1-carboxylic acid N-methoxycarbonylethyl amide
CAS No.:316363-48-1
Molecular Formula:C₁₇H₂₂N₂O₅
Molecular Weight:334.372
Hs Code.:

Synonyms:2-benzyloxycarbonylamino-(1R,2S)-cyclobutane-1-carboxylic acid N-methoxycarbonylethyl amide

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Chemical Property of 2-benzyloxycarbonylamino-(1R,2S)-cyclobutane-1-carboxylic acid N-methoxycarbonylethyl amide

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Technology Process of 2-benzyloxycarbonylamino-(1R,2S)-cyclobutane-1-carboxylic acid N-methoxycarbonylethyl amide

There total 2 articles about 2-benzyloxycarbonylamino-(1R,2S)-cyclobutane-1-carboxylic acid N-methoxycarbonylethyl amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 3196-73-4
methyl 3-aminopropanoate hydrochloride

: 221158-93-6
2-benzyloxycarbonylamino-(1R,2S)-cyclobutane-1-carboxylic acid

: 316363-48-1
2-benzyloxycarbonylamino-(1R,2S)-cyclobutane-1-carboxylic acid N-methoxycarbonylethyl amide

Guidance literature:: With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 1.5h;
DOI:10.1039/c1ob06575k

Reference yield:

: 221158-91-4
methyl 2-benzyloxycarbonylamino-(1R,2S)-cyclobutane-1-carboxylate

: 316363-48-1
2-benzyloxycarbonylamino-(1R,2S)-cyclobutane-1-carboxylic acid N-methoxycarbonylethyl amide

Guidance literature:: Multi-step reaction with 2 steps

1: aq. K₂CO₃ / methanol / 6 h / 20 °C

2: 1-hydroxybenzotriazole; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; Et₃N / dimethylformamide / 20 h / 20 °C

With potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In methanol; N,N-dimethyl-formamide; 1: Hydrolysis / 2: Condensation;
DOI:10.1016/S0957-4166(00)00297-4