(1R,3S)-ethyl 3-(6-bromo-3,5-difluoropyridin-2-ylamino)cyclohexanecarboxylate

Base Information

Chemical Name:(1R,3S)-ethyl 3-(6-bromo-3,5-difluoropyridin-2-ylamino)cyclohexanecarboxylate
CAS No.:1383485-54-8
Molecular Formula:C₁₄H₁₇BrF₂N₂O₂
Molecular Weight:363.202
Hs Code.:

Synonyms:(1R,3S)-ethyl 3-(6-bromo-3,5-difluoropyridin-2-ylamino)cyclohexanecarboxylate

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Chemical Property of (1R,3S)-ethyl 3-(6-bromo-3,5-difluoropyridin-2-ylamino)cyclohexanecarboxylate

Chemical Property:

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Technology Process of (1R,3S)-ethyl 3-(6-bromo-3,5-difluoropyridin-2-ylamino)cyclohexanecarboxylate

There total 3 articles about (1R,3S)-ethyl 3-(6-bromo-3,5-difluoropyridin-2-ylamino)cyclohexanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1186194-66-0
2-bromo-3,5,6-trifluoropyridine

: 53084-60-9,60601-06-1,62456-14-8
ethyl (1R,3S)-3-aminocyclohexanecarboxylate

: 1383485-54-8
(1R,3S)-ethyl 3-(6-bromo-3,5-difluoropyridin-2-ylamino)cyclohexanecarboxylate

Guidance literature:: With triethylamine; In tetrahydrofuran; methanol; at 100 ℃;

Reference yield:

: 227783-08-6
(1S,3R)-3-ethoxycarbonylcyclohexane-1-carboxylic acid

: 1383485-54-8
(1R,3S)-ethyl 3-(6-bromo-3,5-difluoropyridin-2-ylamino)cyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: diphenyl phosphoryl azide; triethylamine / toluene / 1 h / 110 °C

1.2: 70 - 85 °C

2.1: hydrogen / palladium on activated charcoal / ethanol / 20 °C

3.1: triethylamine / tetrahydrofuran; methanol / 100 °C

With diphenyl phosphoryl azide; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; toluene;

Reference yield:

: 1259278-09-5
ethyl (1R,3S)-3-benzyloxycarbonylaminocyclohexane-1-carboxylate

: 1383485-54-8
(1R,3S)-ethyl 3-(6-bromo-3,5-difluoropyridin-2-ylamino)cyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen / palladium on activated charcoal / ethanol / 20 °C

2: triethylamine / tetrahydrofuran; methanol / 100 °C

With hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol;