1,1-dimethylethyl (4R,5S)-[1,3,4,5-tetrahydro-5-(2-methyl-1-propenyl)-1-[(4-methylphenyl)sulfonyl]benz[cd]indol-4-yl]-N-methylcarbamate

Base Information

Chemical Name:1,1-dimethylethyl (4R,5S)-[1,3,4,5-tetrahydro-5-(2-methyl-1-propenyl)-1-[(4-methylphenyl)sulfonyl]benz[cd]indol-4-yl]-N-methylcarbamate
CAS No.:254736-52-2
Molecular Formula:C₂₈H₃₄N₂O₄S
Molecular Weight:494.655
Hs Code.:

Synonyms:1,1-dimethylethyl (4R,5S)-[1,3,4,5-tetrahydro-5-(2-methyl-1-propenyl)-1-[(4-methylphenyl)sulfonyl]benz[cd]indol-4-yl]-N-methylcarbamate

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Chemical Property of 1,1-dimethylethyl (4R,5S)-[1,3,4,5-tetrahydro-5-(2-methyl-1-propenyl)-1-[(4-methylphenyl)sulfonyl]benz[cd]indol-4-yl]-N-methylcarbamate

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Technology Process of 1,1-dimethylethyl (4R,5S)-[1,3,4,5-tetrahydro-5-(2-methyl-1-propenyl)-1-[(4-methylphenyl)sulfonyl]benz[cd]indol-4-yl]-N-methylcarbamate

There total 4 articles about 1,1-dimethylethyl (4R,5S)-[1,3,4,5-tetrahydro-5-(2-methyl-1-propenyl)-1-[(4-methylphenyl)sulfonyl]benz[cd]indol-4-yl]-N-methylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 254736-51-1
1,1-dimethylethyl (4R,5S)-[1,3,4,5-tetrahydro-5-(2-oxopropyl)-1-[(4-methylphenyl)sulfonyl]benz[cd]indol-4-yl]-N-methylcarbamate

: 254736-52-2
1,1-dimethylethyl (4R,5S)-[1,3,4,5-tetrahydro-5-(2-methyl-1-propenyl)-1-[(4-methylphenyl)sulfonyl]benz[cd]indol-4-yl]-N-methylcarbamate

Guidance literature:: With pyridine; In tetrahydrofuran; toluene; at -20 ℃; for 0.5h;
DOI:10.1248/cpb.47.1587

Reference yield:

: methyl [4R-(Z)]-[4-[[(1,1-dimethylethoxy)carbonyl]methylamino]-3,4-dihydro-1-[(4-methylphenyl)sulfonyl]benz[cd]indol-5(1H)-ylidene]acetate

: 254736-52-2
1,1-dimethylethyl (4R,5S)-[1,3,4,5-tetrahydro-5-(2-methyl-1-propenyl)-1-[(4-methylphenyl)sulfonyl]benz[cd]indol-4-yl]-N-methylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / H₂ / 10 percent Pd/C / methanol / 0.5 h

2: pyridine / toluene; tetrahydrofuran / 0.5 h / -20 °C

3: aq. HCl / toluene; tetrahydrofuran; ethyl acetate

4: 84 percent / pyridine / toluene; tetrahydrofuran / 0.5 h / -20 °C

With pyridine; hydrogenchloride; hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; ethyl acetate; toluene; 1: Catalytic hydrogenation / 2: Condensation / 3: Hydrolysis / 4: Substitution;
DOI:10.1248/cpb.47.1587

Reference yield:

: [5-(2-methoxy-allyl)-1-(toluene-4-sulfonyl)-1,3,4,5-tetrahydro-benzo[cd]indol-4-yl]-methyl-carbamic acid tert-butyl ester

: 254736-52-2
1,1-dimethylethyl (4R,5S)-[1,3,4,5-tetrahydro-5-(2-methyl-1-propenyl)-1-[(4-methylphenyl)sulfonyl]benz[cd]indol-4-yl]-N-methylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: aq. HCl / toluene; tetrahydrofuran; ethyl acetate

2: 84 percent / pyridine / toluene; tetrahydrofuran / 0.5 h / -20 °C

With pyridine; hydrogenchloride; In tetrahydrofuran; ethyl acetate; toluene; 1: Hydrolysis / 2: Substitution;
DOI:10.1248/cpb.47.1587