3-Hydroxy-6-methoxy-1,2-benzisoxazole

Base Information

Chemical Name:3-Hydroxy-6-methoxy-1,2-benzisoxazole
CAS No.:89942-57-4
Molecular Formula:C₈H₇NO₃
Molecular Weight:165.148
Hs Code.:
European Community (EC) Number:858-086-8
ChEMBL ID:CHEMBL483504
DSSTox Substance ID:DTXSID401290218
Mol file:89942-57-4.mol

Synonyms:89942-57-4;3-hydroxy-6-methoxy-1,2-benzisoxazole;6-methoxy-2,3-dihydro-1,2-benzoxazol-3-one;6-methoxy-1,2-benzoxazol-3-one;MFCD13180533;6-Methoxybenzisoxazol-3(2H)-one;CHEMBL483504;SCHEMBL1562381;BDBM23176;6-methoxy-1,2-benzoxazol-3-ol;6-Methoxy-benzo[d]isoxazol-3-ol;WVBAYYGFAJXJEX-UHFFFAOYSA-N;6-Methoxy-benzo[d]isoxazol-3-one;DTXSID401290218;6-methoxybenzo[d]isoxazol-3(2H)-one;Benzo[d]isoxazol-3-ol Derivative, 3h;6-Methoxy-1,2-benzoxazol-3(2H)-one;6-Methoxy-1,2-benzisoxazol-3(2H)-one;SY199347;D78694;EN300-201907;Z1255432717

Suppliers and Price of 3-Hydroxy-6-methoxy-1,2-benzisoxazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
6-methoxy-2,3-dihydro-1,2-benzoxazol-3-one
50mg
$ 175.00

AK Scientific
3-Hydroxy-6-methoxy-1,2-benzisoxazole
100mg
$ 289.00

Advanced Chemicals Intermediatesced Chemicals Intermediates
6-Methoxy-benzo[d]isoxazol-3-ol 95%+
1g
$ 616.25

Acints
6-Methoxy-benzo[d]isoxazol-3-ol 95%+
1g
$ 616.25

Total 4 raw suppliers

Chemical Property of 3-Hydroxy-6-methoxy-1,2-benzisoxazole

Chemical Property:

Melting Point:205-207 °C
PKA:13.52±0.20(Predicted)
PSA：55.23000
Density:1.309±0.06 g/cm3(Predicted)
LogP:1.12970
XLogP3:1.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:165.042593085
Heavy Atom Count:12
Complexity:195

Purity/Quality:

99% ^*data from raw suppliers

6-methoxy-2,3-dihydro-1,2-benzoxazol-3-one ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC2=C(C=C1)C(=O)NO2

Technology Process of 3-Hydroxy-6-methoxy-1,2-benzisoxazole

There total 6 articles about 3-Hydroxy-6-methoxy-1,2-benzisoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 90222-58-5
2-hydroxy-4-methoxybenzohydroxamic acid

: 89942-57-4
6-methoxybenzo[d]isoxazol-3(2H)-one

Guidance literature:: With 1,1'-carbonyldiimidazole; In tetrahydrofuran; for 8h; Reflux;

Reference yield:

: 90222-58-5
2-hydroxy-4-methoxybenzohydroxamic acid

: 89942-57-4
3-hydroxy-6-methoxy-1,2-benzisoxazole

Guidance literature:: With 1,1'-carbonyldiimidazole; In tetrahydrofuran; at 50 ℃; for 3.5h; Heating / reflux;

Reference yield:

: 5446-02-6
4-methoxymethylsalicylate

: 89942-57-4
3-hydroxy-6-methoxy-1,2-benzisoxazole

Guidance literature:: Multi-step reaction with 2 steps

1: hydroxylamine hydrochloride; sodium hydroxide / 1,4-dioxane; water / 18 h / 20 °C / Inert atmosphere

2: 1,1'-carbonyldiimidazole / tetrahydrofuran / 20 °C / Inert atmosphere; Reflux

With hydroxylamine hydrochloride; 1,1'-carbonyldiimidazole; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; water;
DOI:10.1021/ml2002955