tert-butyl 3-(1-[3-aminopropyl]indazol-5-ylcarbonylamino)-2(S)-(2,4,6-trimethylbenzenesulfonylamino)propionate

Base Information

Chemical Name:tert-butyl 3-(1-[3-aminopropyl]indazol-5-ylcarbonylamino)-2(S)-(2,4,6-trimethylbenzenesulfonylamino)propionate
CAS No.:192945-02-1
Molecular Formula:C₂₇H₃₇N₅O₅S
Molecular Weight:543.687
Hs Code.:

Synonyms:tert-butyl 3-(1-[3-aminopropyl]indazol-5-ylcarbonylamino)-2(S)-(2,4,6-trimethylbenzenesulfonylamino)propionate

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Chemical Property of tert-butyl 3-(1-[3-aminopropyl]indazol-5-ylcarbonylamino)-2(S)-(2,4,6-trimethylbenzenesulfonylamino)propionate

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Technology Process of tert-butyl 3-(1-[3-aminopropyl]indazol-5-ylcarbonylamino)-2(S)-(2,4,6-trimethylbenzenesulfonylamino)propionate

There total 6 articles about tert-butyl 3-(1-[3-aminopropyl]indazol-5-ylcarbonylamino)-2(S)-(2,4,6-trimethylbenzenesulfonylamino)propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 192945-01-0
tert-butyl 3-(1-[3-benzyloxycarbonylaminopropyl]indazol-5-ylcarbonylamino)-2(S)-(2,4,6-trimethylbenzenesulfonylamino)propionate

: 192945-02-1
tert-butyl 3-(1-[3-aminopropyl]indazol-5-ylcarbonylamino)-2(S)-(2,4,6-trimethylbenzenesulfonylamino)propionate

Guidance literature:: With cyclohexa-1,4-diene; palladium dihydroxide; In methanol; for 4h; Heating;
DOI:10.1021/jm990049j

Reference yield: 85.0%

: 192945-02-1
tert-butyl 3-(1-[3-aminopropyl]indazol-5-ylcarbonylamino)-2(S)-(2,4,6-trimethylbenzenesulfonylamino)propionate

Guidance literature:

Reference yield:

: C₁₃H₁₇N₃O₂*1.05HCl

: 192945-02-1
tert-butyl 3-(1-[3-aminopropyl]indazol-5-ylcarbonylamino)-2(S)-(2,4,6-trimethylbenzenesulfonylamino)propionate

Guidance literature:: Multi-step reaction with 4 steps

1: 49 percent / Et₃N / CH₂Cl₂ / 16 h

2: 56 percent / aq. LiOH / ethanol; tetrahydrofuran / 120 h

3: 68 percent / HOBT; DCC / tetrahydrofuran / 24 h

4: 85 percent / 1,4-cyclohexadiene / Pd(OH)2/C / methanol / 4 h / Heating

With lithium hydroxide; cyclohexa-1,4-diene; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; palladium dihydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; 1: Condensation / 2: Hydrolysis / 3: Condensation / 4: Hydrogenolysis;
DOI:10.1021/jm990049j