6-[1-cyclobutyl-4-[[3,5-cis-3,4,5-trimethyl-1-piperazinyl]carbonyl]-1H-pyrazol-5-yl]-13-cyclohexyl-3-methoxy-N-[(2-methylpropyl)sulfonyl]-7H-indolo[2,1-a][2]benzazepine-10-carboxamide trifluoroacetate

Base Information

Chemical Name:6-[1-cyclobutyl-4-[[3,5-cis-3,4,5-trimethyl-1-piperazinyl]carbonyl]-1H-pyrazol-5-yl]-13-cyclohexyl-3-methoxy-N-[(2-methylpropyl)sulfonyl]-7H-indolo[2,1-a][2]benzazepine-10-carboxamide trifluoroacetate
CAS No.:1195778-86-9
Molecular Formula:C₂HF₃O₂*C₄₄H₅₆N₆O₅S
Molecular Weight:895.056
Hs Code.:

6-[1-cyclobutyl-4-[[3,5-cis-3,4,5-trimethyl-1-piperazinyl]carbonyl]-1H-pyrazol-5-yl]-13-cyclohexyl-3-methoxy-N-[(2-methylpropyl)sulfonyl]-7H-indolo[2,1-a][2]benzazepine-10-carboxamide trifluoroacetate

Synonyms:6-[1-cyclobutyl-4-[[3,5-cis-3,4,5-trimethyl-1-piperazinyl]carbonyl]-1H-pyrazol-5-yl]-13-cyclohexyl-3-methoxy-N-[(2-methylpropyl)sulfonyl]-7H-indolo[2,1-a][2]benzazepine-10-carboxamide trifluoroacetate

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Chemical Property of 6-[1-cyclobutyl-4-[[3,5-cis-3,4,5-trimethyl-1-piperazinyl]carbonyl]-1H-pyrazol-5-yl]-13-cyclohexyl-3-methoxy-N-[(2-methylpropyl)sulfonyl]-7H-indolo[2,1-a][2]benzazepine-10-carboxamide trifluoroacetate

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Technology Process of 6-[1-cyclobutyl-4-[[3,5-cis-3,4,5-trimethyl-1-piperazinyl]carbonyl]-1H-pyrazol-5-yl]-13-cyclohexyl-3-methoxy-N-[(2-methylpropyl)sulfonyl]-7H-indolo[2,1-a][2]benzazepine-10-carboxamide trifluoroacetate

There total 5 articles about 6-[1-cyclobutyl-4-[[3,5-cis-3,4,5-trimethyl-1-piperazinyl]carbonyl]-1H-pyrazol-5-yl]-13-cyclohexyl-3-methoxy-N-[(2-methylpropyl)sulfonyl]-7H-indolo[2,1-a][2]benzazepine-10-carboxamide trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: (2R,6S)-1,2,6-trimethylpiperazine dihydrochloride

: 1195778-74-5
1-cyclobutyl-5-[13-cyclohexyl-3-methoxy-10-[[[(2-methylpropyl)sulfonyl]amino]carbonyl]-7H-indolo[2,1-a][2]benzazepin-6-yl]-1H-pyrazole-4-carboxylic acid

: 76-05-1
trifluoroacetic acid

: 1195778-86-9
6-[1-cyclobutyl-4-[[3,5-cis-3,4,5-trimethyl-1-piperazinyl]carbonyl]-1H-pyrazol-5-yl]-13-cyclohexyl-3-methoxy-N-[(2-methylpropyl)sulfonyl]-7H-indolo[2,1-a][2]benzazepine-10-carboxamide trifluoroacetate

Guidance literature:: 1-cyclobutyl-5-[13-cyclohexyl-3-methoxy-10-[[[(2-methylpropyl)sulfonyl]amino]carbonyl]-7H-indolo[2,1-a][2]benzazepin-6-yl]-1H-pyrazole-4-carboxylic acid; With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 20 ℃; for 0.25h;

(2R,6S)-1,2,6-trimethylpiperazine dihydrochloride; In dimethyl sulfoxide; at 20 ℃;

trifluoroacetic acid; In water; dimethyl sulfoxide; acetonitrile;

Reference yield:

: 1127234-87-0
13-cyclohexyl-10-[(1,1-dimethylethoxy)carbonyl]-3-methoxy-beta-oxo-7H-indolo[2,1-a][2]benzazepine-6-propanoic acid ethyl ester

: 1195778-86-9
6-[1-cyclobutyl-4-[[3,5-cis-3,4,5-trimethyl-1-piperazinyl]carbonyl]-1H-pyrazol-5-yl]-13-cyclohexyl-3-methoxy-N-[(2-methylpropyl)sulfonyl]-7H-indolo[2,1-a][2]benzazepine-10-carboxamide trifluoroacetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: 2.75 h / 110 °C / Inert atmosphere

2.1: triethylamine / ethanol / 2 h / 160 °C / microwave condition

3.1: trifluoroacetic acid / 1,2-dichloro-ethane / 20 °C

4.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 1 h / 60 °C

4.2: 4 h / 60 °C

5.1: sodium hydroxide / tetrahydrofuran; ethanol / 96 h / 20 °C

6.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 0.25 h / 20 °C

6.2: 20 °C

With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; N-ethyl-N,N-diisopropylamine; 1,1'-carbonyldiimidazole; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; ethanol; dimethyl sulfoxide; 1,2-dichloro-ethane;

Reference yield:

: 1195781-72-6
6-[1-cyclobutyl-4-(ethoxycarbonyl)-1H-pyrazol-5-yl]-13-cyclohexyl-3-methoxy-7H-indolo[2,1-a][2]benzazepine-10-carboxylic acid

: 1195778-86-9
6-[1-cyclobutyl-4-[[3,5-cis-3,4,5-trimethyl-1-piperazinyl]carbonyl]-1H-pyrazol-5-yl]-13-cyclohexyl-3-methoxy-N-[(2-methylpropyl)sulfonyl]-7H-indolo[2,1-a][2]benzazepine-10-carboxamide trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 1 h / 60 °C

1.2: 4 h / 60 °C

2.1: sodium hydroxide / tetrahydrofuran; ethanol / 96 h / 20 °C

3.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 0.25 h / 20 °C

3.2: 20 °C

With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; 1,1'-carbonyldiimidazole; sodium hydroxide; In tetrahydrofuran; ethanol; dimethyl sulfoxide;