4-{2-[(R)-2-((S)-2-Hydroxy-3-phenoxy-propylamino)-propyl]-thiazol-5-yl}-butyric acid ethyl ester

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Chemical Name:4-{2-[(R)-2-((S)-2-Hydroxy-3-phenoxy-propylamino)-propyl]-thiazol-5-yl}-butyric acid ethyl ester
CAS No.:159877-85-7
Molecular Formula:C₂₁H₃₀N₂O₄S
Molecular Weight:406.546
Hs Code.:

Synonyms:4-{2-[(R)-2-((S)-2-Hydroxy-3-phenoxy-propylamino)-propyl]-thiazol-5-yl}-butyric acid ethyl ester

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Chemical Property of 4-{2-[(R)-2-((S)-2-Hydroxy-3-phenoxy-propylamino)-propyl]-thiazol-5-yl}-butyric acid ethyl ester

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Technology Process of 4-{2-[(R)-2-((S)-2-Hydroxy-3-phenoxy-propylamino)-propyl]-thiazol-5-yl}-butyric acid ethyl ester

There total 6 articles about 4-{2-[(R)-2-((S)-2-Hydroxy-3-phenoxy-propylamino)-propyl]-thiazol-5-yl}-butyric acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 71031-03-3,71031-02-2
(R)-phenyl glycidyl ether

: 159877-84-6
(R)-2-(2-Aminopropyl)-5-thiazolebutanoic acid, ethyl ester

: 159877-85-7
4-{2-[(R)-2-((S)-2-Hydroxy-3-phenoxy-propylamino)-propyl]-thiazol-5-yl}-butyric acid ethyl ester

Guidance literature:: at 60 ℃;
DOI:10.1016/0960-894X(96)00417-9

Reference yield:

: 502-44-3,24980-41-4,80137-66-2
hexahydro-2H-oxepin-2-one

: 159877-85-7
4-{2-[(R)-2-((S)-2-Hydroxy-3-phenoxy-propylamino)-propyl]-thiazol-5-yl}-butyric acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: H₂SO₄ / Heating

2: PCC / CH₂Cl₂ / Ambient temperature

3: 44 percent / Br₂ / diethyl ether; dioxane / 0 °C

4: 50 percent / dimethylformamide / 50 - 60 °C

5: 47 percent / 60 °C

With sulfuric acid; bromine; pyridinium chlorochromate; In 1,4-dioxane; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/0960-894X(96)00417-9

Reference yield:

: 5299-60-5
6-hydroxy-hexanoic acid ethyl ester

: 159877-85-7
4-{2-[(R)-2-((S)-2-Hydroxy-3-phenoxy-propylamino)-propyl]-thiazol-5-yl}-butyric acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: PCC / CH₂Cl₂ / Ambient temperature

2: 44 percent / Br₂ / diethyl ether; dioxane / 0 °C

3: 50 percent / dimethylformamide / 50 - 60 °C

4: 47 percent / 60 °C

With bromine; pyridinium chlorochromate; In 1,4-dioxane; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/0960-894X(96)00417-9