1-(Piperidin-2-yl)propan-2-ol

Base Information

• Chemical Name: 1-(Piperidin-2-yl)propan-2-ol
• CAS No.: 10047-06-0
• Molecular Formula: C₈H₁₇NO
• Molecular Weight: 143.229
• European Community (EC) Number: 853-850-7
• Nikkaji Number: J505.930E
• Wikidata: Q110202051
• Mol file: 10047-06-0.mol

Synonyms:1-(piperidin-2-yl)propan-2-ol;10047-06-0;1-piperidin-2-ylpropan-2-ol;SCHEMBL456091;AKOS006350088;EN300-189971;Z1203731039

Chemical Property of 1-(Piperidin-2-yl)propan-2-ol

Chemical Property:

• XLogP3: 0.8
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 143.131014166
• Heavy Atom Count: 10
• Complexity: 95.3

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(CC1CCCCN1)O

Technology Process of 1-(Piperidin-2-yl)propan-2-ol

There total 34 articles about 1-(Piperidin-2-yl)propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

benzyl 2-(2-hydroxypropyl)piperidine-1-carboxylate (14199-09-8) → (+/-) Sedridine (501-83-7,5320-51-4,10047-06-0,26171-47-1,26619-80-7,26619-87-4,26623-96-1) + (+/-) allosedridine (501-83-7,5320-51-4,10047-06-0,26171-47-1,26619-80-7,26619-87-4,26623-96-1)

Guidance literature:

With palladium on activated charcoal; hydrogen; In ethyl acetate; at 30 ℃; for 4h;

DOI:10.1016/j.tetlet.2015.03.001

Reference yield: 98.0%

benzyl 2-(2-hydroxypropyl)piperidine-1-carboxylate (14199-09-8) → (+/-) Sedridine (501-83-7,5320-51-4,10047-06-0,26171-47-1,26619-80-7,26619-87-4,26623-96-1) + (+/-) allosedridine (501-83-7,5320-51-4,10047-06-0,26171-47-1,26619-80-7,26619-87-4,26623-96-1)

Guidance literature:

With palladium on activated charcoal; hydrogen; In ethyl acetate; at 30 ℃; for 4h;

DOI:10.1016/j.tetlet.2015.03.001

Reference yield:

2-acetonylpyridine (6302-02-9) → (α-hexahydropyridylidene)-propanone (60807-16-1) + sedridine (10047-06-0) + isopelletierine (4396-01-4) + 1-pyridin-2-yl-propan-2-ol (5307-19-7)

Guidance literature:

With hydrogen; In tetrahydrofuran; at 30 ℃; for 1h; under 3750.38 Torr; Catalytic behavior; Autoclave; Glovebox;

DOI:10.1016/j.jcat.2017.08.010

upstream raw materials:

2-acetonylpyridine

(3RS,5RS)-3-methylhexahydro-3H-pyrido[1,2-c][1,3]oxazin-1-one

2-methyl-hexahydro-isoxazolo[2,3-a]pyridine

N-hydroxypiperidine