methyl 2-(3'-((2R,3S,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)-[1,1'-biphenyl]-3-yl)acetate

Base Information

Chemical Name:methyl 2-(3'-((2R,3S,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)-[1,1'-biphenyl]-3-yl)acetate
CAS No.:1453851-97-2
Molecular Formula:C₂₁H₂₄O₇
Molecular Weight:388.417
Hs Code.:

Synonyms:methyl 2-(3'-((2R,3S,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)-[1,1'-biphenyl]-3-yl)acetate

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Chemical Property of methyl 2-(3'-((2R,3S,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)-[1,1'-biphenyl]-3-yl)acetate

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Technology Process of methyl 2-(3'-((2R,3S,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)-[1,1'-biphenyl]-3-yl)acetate

There total 6 articles about methyl 2-(3'-((2R,3S,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)-[1,1'-biphenyl]-3-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 643094-11-5
[3-(2-methoxy-2-oxo-ethyl)phenyl]boronic acid

: 1453855-50-9
((2R,3S,4R,5S,6R)-3-acetoxy-4,5-dihydroxy-6-(3-(trifluoromethylsulfonyloxy)phenyl)tetrahydro-2H-pyran-2-yl)methyl acetate

: 1453851-97-2
methyl 2-(3'-((2R,3S,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)-[1,1'-biphenyl]-3-yl)acetate

Guidance literature:: [3-(2-methoxy-2-oxo-ethyl)phenyl]boronic acid; ((2R,3S,4R,5S,6R)-3-acetoxy-4,5-dihydroxy-6-(3-(trifluoromethylsulfonyloxy)phenyl)tetrahydro-2H-pyran-2-yl)methyl acetate; With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate; In 1,4-dioxane; at 95 ℃; for 18h; Inert atmosphere;

With sodium methylate; In methanol; at 20 ℃; for 18h;

Reference yield:

: 1453855-65-6
[(2R,3S,4R,5S,6R)-3-acetoxy-6-[3-[tert-butyl(dimethyl)silyl]oxyphenyl]-4,5-dihydroxytetrahydropyran-2-yl]methyl acetate

: 1453851-97-2
methyl 2-(3'-((2R,3S,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)-[1,1'-biphenyl]-3-yl)acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic acid; tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h

2.1: triethylamine / dichloromethane / 20 °C

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate / 1,4-dioxane / 18 h / 95 °C / Inert atmosphere

3.2: 18 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutyl ammonium fluoride; sodium hydrogencarbonate; acetic acid; triethylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane;

Reference yield:

: 1453855-49-6
((2R,3S,4R,5S,6R)-3-acetoxy-4,5-dihydroxy-6-(3-hydroxyphenyl)tetrahydro-2H-pyran-2-yl)methyl acetate

: 1453851-97-2
methyl 2-(3'-((2R,3S,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)-[1,1'-biphenyl]-3-yl)acetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / dichloromethane / 20 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate / 1,4-dioxane / 18 h / 95 °C / Inert atmosphere

2.2: 18 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate; triethylamine; In 1,4-dioxane; dichloromethane;