(Z)-21-(4-Methyl-2,6,7-trioxa-bicyclo[2.2.2]oct-1-yl)-henicos-11-enoic acid benzyl ester

Base Information

Chemical Name:(Z)-21-(4-Methyl-2,6,7-trioxa-bicyclo[2.2.2]oct-1-yl)-henicos-11-enoic acid benzyl ester
CAS No.:850347-51-2
Molecular Formula:C₃₄H₅₄O₅
Molecular Weight:542.8
Hs Code.:

Synonyms:(Z)-21-(4-Methyl-2,6,7-trioxa-bicyclo[2.2.2]oct-1-yl)-henicos-11-enoic acid benzyl ester

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Chemical Property of (Z)-21-(4-Methyl-2,6,7-trioxa-bicyclo[2.2.2]oct-1-yl)-henicos-11-enoic acid benzyl ester

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Technology Process of (Z)-21-(4-Methyl-2,6,7-trioxa-bicyclo[2.2.2]oct-1-yl)-henicos-11-enoic acid benzyl ester

There total 7 articles about (Z)-21-(4-Methyl-2,6,7-trioxa-bicyclo[2.2.2]oct-1-yl)-henicos-11-enoic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 850347-43-2
11-oxo-undecanoic acid benzyl ester

: [10-(4-methyl-2,6,7-trioxa-bicyclo[2.2.2]oct-1-yl)-decyl]-triphenyl-phosphonium; iodide

: 850347-51-2
(Z)-21-(4-Methyl-2,6,7-trioxa-bicyclo[2.2.2]oct-1-yl)-henicos-11-enoic acid benzyl ester

Guidance literature:: [10-(4-methyl-2,6,7-trioxa-bicyclo[2.2.2]oct-1-yl)-decyl]-triphenyl-phosphonium; iodide; With n-butyllithium; In tetrahydrofuran; hexane; at -20 ℃;

11-oxo-undecanoic acid benzyl ester; With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; In tetrahydrofuran; hexane; at -78 - 20 ℃;
DOI:10.1021/jo048167o

Reference yield:

: 63632-65-5
11-iodo-undecanoic acid

: 850347-51-2
(Z)-21-(4-Methyl-2,6,7-trioxa-bicyclo[2.2.2]oct-1-yl)-henicos-11-enoic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 91 percent / dicyclohexylcarbodiimide; 4-(dimethylamino)pyridine / CH₂Cl₂ / 20 °C

2.1: 68 percent / BF₃*Et₂O / CH₂Cl₂ / 0 °C

3.1: benzene; toluene / Heating

4.1: n-BuLi / tetrahydrofuran; hexane / -20 °C

4.2: 5.08 g / DMPU / tetrahydrofuran; hexane / -78 - 20 °C

With dmap; n-butyllithium; boron trifluoride diethyl etherate; dicyclohexyl-carbodiimide; In tetrahydrofuran; hexane; dichloromethane; toluene; benzene; 4.2: Wittig reaction;
DOI:10.1021/jo048167o

Reference yield:

: 155438-99-6
11-iodo-undecanoic acid benzyl ester

: 850347-51-2
(Z)-21-(4-Methyl-2,6,7-trioxa-bicyclo[2.2.2]oct-1-yl)-henicos-11-enoic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 96 percent / NaHCO₃; DMSO / 150 °C

2.1: n-BuLi / tetrahydrofuran; hexane / -20 °C

2.2: 5.08 g / DMPU / tetrahydrofuran; hexane / -78 - 20 °C

With n-butyllithium; sodium hydrogencarbonate; dimethyl sulfoxide; In tetrahydrofuran; hexane; 2.2: Wittig reaction;
DOI:10.1021/jo048167o