(3S,4R)-4-Amino-6-(3-benzyl-piperidine-1-sulfonyl)-2,2-dimethyl-chroman-3-ol

Base Information

Chemical Name:(3S,4R)-4-Amino-6-(3-benzyl-piperidine-1-sulfonyl)-2,2-dimethyl-chroman-3-ol
CAS No.:1053622-53-9
Molecular Formula:C₂₃H₃₀N₂O₄S
Molecular Weight:430.568
Hs Code.:

Synonyms:(3S,4R)-4-Amino-6-(3-benzyl-piperidine-1-sulfonyl)-2,2-dimethyl-chroman-3-ol

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Chemical Property of (3S,4R)-4-Amino-6-(3-benzyl-piperidine-1-sulfonyl)-2,2-dimethyl-chroman-3-ol

Chemical Property:

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Technology Process of (3S,4R)-4-Amino-6-(3-benzyl-piperidine-1-sulfonyl)-2,2-dimethyl-chroman-3-ol

There total 4 articles about (3S,4R)-4-Amino-6-(3-benzyl-piperidine-1-sulfonyl)-2,2-dimethyl-chroman-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1026490-94-7
3-benzyl-1-(2,2-dimethyl-1a,7b-dihydro-2H-1,3-dioxa-cyclopropa[a]naphthalene-6-sulfonyl)-piperidine

: 1053622-53-9
(3S,4R)-4-Amino-6-(3-benzyl-piperidine-1-sulfonyl)-2,2-dimethyl-chroman-3-ol

Guidance literature:: With ammonium hydroxide; In tetrahydrofuran; isopropyl alcohol; at 75 ℃; for 24h;
DOI:10.1021/jm990196h

Reference yield:

: 13603-25-3
3-benzylpiperidine

: 1053622-53-9
(3S,4R)-4-Amino-6-(3-benzyl-piperidine-1-sulfonyl)-2,2-dimethyl-chroman-3-ol

Guidance literature:: Multi-step reaction with 3 steps

1: CH₂Cl₂ / 2 h / 20 °C

2: sodium hypochlorite; (S,S)-(+)-Jacobsen's catalyst; 4-phenylpyridine-N-oxide / H₂O / 18 h / 0 °C / pH 11.3

3: ammonium hydroxide / tetrahydrofuran; propan-2-ol / 24 h / 75 °C

With ammonium hydroxide; sodium hypochlorite; 4-Phenylpyridine 1-oxide; Jacobsen's catalyst; In tetrahydrofuran; dichloromethane; water; isopropyl alcohol; 1: Acylation / 2: Epoxidation / 3: Ring cleavage;
DOI:10.1021/jm990196h

Reference yield:

: 185316-64-7
2,2-dimethyl-2H-1-benzopyran-6-sulfonyl chloride

: 1053622-53-9
(3S,4R)-4-Amino-6-(3-benzyl-piperidine-1-sulfonyl)-2,2-dimethyl-chroman-3-ol

Guidance literature:: Multi-step reaction with 3 steps

1: CH₂Cl₂ / 2 h / 20 °C

2: sodium hypochlorite; (S,S)-(+)-Jacobsen's catalyst; 4-phenylpyridine-N-oxide / H₂O / 18 h / 0 °C / pH 11.3

3: ammonium hydroxide / tetrahydrofuran; propan-2-ol / 24 h / 75 °C

With ammonium hydroxide; sodium hypochlorite; 4-Phenylpyridine 1-oxide; Jacobsen's catalyst; In tetrahydrofuran; dichloromethane; water; isopropyl alcohol; 1: Acylation / 2: Epoxidation / 3: Ring cleavage;
DOI:10.1021/jm990196h