5-(6-methoxynaphth-2-yl)-2-(2-methoxyphenyl)-N-methyl-4-(4-trifluoromethylphenyl)imidazole

Base Information

• Chemical Name: 5-(6-methoxynaphth-2-yl)-2-(2-methoxyphenyl)-N-methyl-4-(4-trifluoromethylphenyl)imidazole
• CAS No.: 1401316-04-8
• Molecular Formula: C₂₉H₂₃F₃N₂O₂
• Molecular Weight: 488.509

Synonyms:5-(6-methoxynaphth-2-yl)-2-(2-methoxyphenyl)-N-methyl-4-(4-trifluoromethylphenyl)imidazole

Chemical Property of 5-(6-methoxynaphth-2-yl)-2-(2-methoxyphenyl)-N-methyl-4-(4-trifluoromethylphenyl)imidazole

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Technology Process of 5-(6-methoxynaphth-2-yl)-2-(2-methoxyphenyl)-N-methyl-4-(4-trifluoromethylphenyl)imidazole

There total 3 articles about 5-(6-methoxynaphth-2-yl)-2-(2-methoxyphenyl)-N-methyl-4-(4-trifluoromethylphenyl)imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

4-Iodobenzotrifluoride (455-13-0) + 1-methyl-2-(2-methoxyphenyl)-5-(6-methoxy-2-naphthyl)-1H-imidazole (1278587-40-8) → 5-(6-methoxynaphth-2-yl)-2-(2-methoxyphenyl)-N-methyl-4-(4-trifluoromethylphenyl)imidazole (1401316-04-8)

Guidance literature:

With [Pd(phen)2](PF₆)2; caesium carbonate; In N,N-dimethyl acetamide; at 150 ℃; Inert atmosphere;

DOI:10.1021/jo301621t

Reference yield:

4-iodoanisol (529-28-2) → 5-(6-methoxynaphth-2-yl)-2-(2-methoxyphenyl)-N-methyl-4-(4-trifluoromethylphenyl)imidazole (1401316-04-8)

Guidance literature:

Multi-step reaction with 2 steps

1: [Pd(phen)2](PF₆)2; caesium carbonate / N,N-dimethyl acetamide / 150 °C / Inert atmosphere

2: [Pd(phen)2](PF₆)2; caesium carbonate / N,N-dimethyl acetamide / 150 °C / Inert atmosphere

With [Pd(phen)2](PF₆)2; caesium carbonate; In N,N-dimethyl acetamide;

DOI:10.1021/jo301621t

Reference yield:

5-(6-methoxynaphthalen-2-yl)-1-methyl-1H-imidazole (1111266-85-3) → 5-(6-methoxynaphth-2-yl)-2-(2-methoxyphenyl)-N-methyl-4-(4-trifluoromethylphenyl)imidazole (1401316-04-8)

Guidance literature:

Multi-step reaction with 2 steps

1: [Pd(phen)2](PF₆)2; caesium carbonate / N,N-dimethyl acetamide / 150 °C / Inert atmosphere

2: [Pd(phen)2](PF₆)2; caesium carbonate / N,N-dimethyl acetamide / 150 °C / Inert atmosphere

With [Pd(phen)2](PF₆)2; caesium carbonate; In N,N-dimethyl acetamide;

DOI:10.1021/jo301621t

upstream raw materials:

4-Iodobenzotrifluoride

1-methyl-2-(2-methoxyphenyl)-5-(6-methoxy-2-naphthyl)-1H-imidazole

4-iodoanisol

5-(6-methoxynaphthalen-2-yl)-1-methyl-1H-imidazole

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