(3S,5S,6R)-3-amino-5-(2-fluoro-3-methylphenyl)-6-methyl-1-(2,2,2-trifluoroethyl)piperidin-2-one

Base Information

Chemical Name:(3S,5S,6R)-3-amino-5-(2-fluoro-3-methylphenyl)-6-methyl-1-(2,2,2-trifluoroethyl)piperidin-2-one
CAS No.:1375541-56-2
Molecular Formula:C₁₅H₁₈F₄N₂O
Molecular Weight:318.314
Hs Code.:

Synonyms:(3S,5S,6R)-3-amino-5-(2-fluoro-3-methylphenyl)-6-methyl-1-(2,2,2-trifluoroethyl)piperidin-2-one

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Chemical Property of (3S,5S,6R)-3-amino-5-(2-fluoro-3-methylphenyl)-6-methyl-1-(2,2,2-trifluoroethyl)piperidin-2-one

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Technology Process of (3S,5S,6R)-3-amino-5-(2-fluoro-3-methylphenyl)-6-methyl-1-(2,2,2-trifluoroethyl)piperidin-2-one

There total 3 articles about (3S,5S,6R)-3-amino-5-(2-fluoro-3-methylphenyl)-6-methyl-1-(2,2,2-trifluoroethyl)piperidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1375541-54-0
5-(2-fluoro-3-methylphenyl)-6-methyl-3-nitro-1-(2,2,2-trifluoroethyl)pyridin-2(1H)-one

: 1375541-56-2
(3S,5S,6R)-3-amino-5-(2-fluoro-3-methylphenyl)-6-methyl-1-(2,2,2-trifluoroethyl)piperidin-2-one

: (3R,5R,6S)-3-amino-5-(2-fluoro-3-methylphenyl)-6-methyl-1-(2,2,2-trifluoroethyl)piperidin-2-one

Guidance literature:: 5-(2-fluoro-3-methylphenyl)-6-methyl-3-nitro-1-(2,2,2-trifluoroethyl)pyridin-2(1H)-one; With hydrogenchloride; hydrogen; platinum(IV) oxide; In methanol; water; at 23 ℃; for 5h; under 2585.81 Torr;

With sodium hydrogencarbonate; In water; ethyl acetate;

With diethylamine; In ethanol; hexane; Resolution of racemate;

Reference yield:

: 54923-31-8
5-bromo-6-methyl-1,2-dihydropyridin-2-one

: 1375541-56-2
(3S,5S,6R)-3-amino-5-(2-fluoro-3-methylphenyl)-6-methyl-1-(2,2,2-trifluoroethyl)piperidin-2-one

: (3R,5R,6S)-3-amino-5-(2-fluoro-3-methylphenyl)-6-methyl-1-(2,2,2-trifluoroethyl)piperidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: caesium carbonate / 1,4-dioxane / 1.5 h / 66 °C

1.2: 16 h / 23 °C

2.1: potassium fluoride / bis(tri-t-butylphosphine)palladium⁽⁰⁾ / tetrahydrofuran / 0.5 h / 66 °C

3.1: hydrogenchloride; hydrogen / platinum(IV) oxide / water; methanol / 5 h / 23 °C / 2585.81 Torr

3.3: ChiralCel_.(R). OD column / Resolution of racemate

With hydrogenchloride; potassium fluoride; hydrogen; caesium carbonate; platinum(IV) oxide; bis(tri-t-butylphosphine)palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; water;

Reference yield:

: 1375541-52-8
5-bromo-6-methyl-3-nitro-1-(2,2,2-trifluoroethyl)pyridin-2(1H)-one

: 1375541-56-2
(3S,5S,6R)-3-amino-5-(2-fluoro-3-methylphenyl)-6-methyl-1-(2,2,2-trifluoroethyl)piperidin-2-one

: (3R,5R,6S)-3-amino-5-(2-fluoro-3-methylphenyl)-6-methyl-1-(2,2,2-trifluoroethyl)piperidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium fluoride / bis(tri-t-butylphosphine)palladium⁽⁰⁾ / tetrahydrofuran / 0.5 h / 66 °C

2.1: hydrogenchloride; hydrogen / platinum(IV) oxide / water; methanol / 5 h / 23 °C / 2585.81 Torr

2.3: ChiralCel_.(R). OD column / Resolution of racemate

With hydrogenchloride; potassium fluoride; hydrogen; platinum(IV) oxide; bis(tri-t-butylphosphine)palladium⁽⁰⁾; In tetrahydrofuran; methanol; water;