8-acetoxy-4-(2-(1,1-diphenylethoxy)ethyl)-3-oxo-3,4-dihydro-2H-1,4-benzoxazine

Base Information

• Chemical Name: 8-acetoxy-4-(2-(1,1-diphenylethoxy)ethyl)-3-oxo-3,4-dihydro-2H-1,4-benzoxazine
• CAS No.: 258532-83-1
• Molecular Formula: C₂₆H₂₅NO₅
• Molecular Weight: 431.488
• Mol file: 258532-83-1.mol

Synonyms:8-acetoxy-4-(2-(1,1-diphenylethoxy)ethyl)-3-oxo-3,4-dihydro-2H-1,4-benzoxazine

Chemical Property of 8-acetoxy-4-(2-(1,1-diphenylethoxy)ethyl)-3-oxo-3,4-dihydro-2H-1,4-benzoxazine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 8-acetoxy-4-(2-(1,1-diphenylethoxy)ethyl)-3-oxo-3,4-dihydro-2H-1,4-benzoxazine

There total 5 articles about 8-acetoxy-4-(2-(1,1-diphenylethoxy)ethyl)-3-oxo-3,4-dihydro-2H-1,4-benzoxazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

8-acetoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazine (258532-81-9) + 2-(1,1-diphenylethoxy)ethanol (6193-82-4) + Toluene-2-sulfonyl chloride (133-59-5) → 8-acetoxy-4-(2-(1,1-diphenylethoxy)ethyl)-3-oxo-3,4-dihydro-2H-1,4-benzoxazine (258532-83-1)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;

Reference yield:

8-acetoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazine (258532-81-9) + 2-(1,1-diphenylethoxy)ethyl tosylate (881830-16-6) → 8-acetoxy-4-(2-(1,1-diphenylethoxy)ethyl)-3-oxo-3,4-dihydro-2H-1,4-benzoxazine (258532-83-1)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1016/j.bmc.2005.10.050

Reference yield:

8-hydroxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazine (258532-76-2) → 8-acetoxy-4-(2-(1,1-diphenylethoxy)ethyl)-3-oxo-3,4-dihydro-2H-1,4-benzoxazine (258532-83-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 94 percent / pyridine / toluene / 24 h / 20 °C

2: 429 mg / sodium hydride / dimethylformamide / 20 °C

With pyridine; sodium hydride; In N,N-dimethyl-formamide; toluene;

DOI:10.1016/j.bmc.2005.10.050

upstream raw materials:

8-acetoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazine

2-(1,1-diphenylethoxy)ethyl tosylate

8-hydroxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazine

2-(1,1-diphenylethoxy)ethanol

Downstream raw materials:

methyl (4-(2-(1,1-diphenylethoxy)ethyl)-3,4-dihydro-2H-1,4-benzoxazin-8-yloxy)acetate

4-(2-(1,1-diphenylethoxy)ethyl)-8-hydroxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazine

acetic acid 4-[2-(1,1-diphenyl-ethoxy)-ethyl]-3,4-dihydro-2H-benzo[1,4]oxazin-8-yl ester