6-(N-(3-(benzyloxy)-2-((4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methyl)propyl)methylsulfonamido)-5-cyclopropyl-N-ethyl-2-(4-fluorophenyl)benzofuran-3-carboxamide

Base Information

Chemical Name:6-(N-(3-(benzyloxy)-2-((4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methyl)propyl)methylsulfonamido)-5-cyclopropyl-N-ethyl-2-(4-fluorophenyl)benzofuran-3-carboxamide
CAS No.:1378429-59-4
Molecular Formula:C₃₈H₄₆BFN₂O₇S
Molecular Weight:704.668
Hs Code.:

6-(N-(3-(benzyloxy)-2-((4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methyl)propyl)methylsulfonamido)-5-cyclopropyl-N-ethyl-2-(4-fluorophenyl)benzofuran-3-carboxamide

Synonyms:6-(N-(3-(benzyloxy)-2-((4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methyl)propyl)methylsulfonamido)-5-cyclopropyl-N-ethyl-2-(4-fluorophenyl)benzofuran-3-carboxamide

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Chemical Property of 6-(N-(3-(benzyloxy)-2-((4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methyl)propyl)methylsulfonamido)-5-cyclopropyl-N-ethyl-2-(4-fluorophenyl)benzofuran-3-carboxamide

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Technology Process of 6-(N-(3-(benzyloxy)-2-((4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methyl)propyl)methylsulfonamido)-5-cyclopropyl-N-ethyl-2-(4-fluorophenyl)benzofuran-3-carboxamide

There total 3 articles about 6-(N-(3-(benzyloxy)-2-((4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methyl)propyl)methylsulfonamido)-5-cyclopropyl-N-ethyl-2-(4-fluorophenyl)benzofuran-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1378429-58-3
6-(N-(2-(benzyloxymethyl)allyl)methylsulfonamido)-5-cyclopropyl-N-ethyl-2-(4-fluorophenyl)benzofuran-3-carboxamide

: 25015-63-8
4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane

: 1378429-59-4
6-(N-(3-(benzyloxy)-2-((4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methyl)propyl)methylsulfonamido)-5-cyclopropyl-N-ethyl-2-(4-fluorophenyl)benzofuran-3-carboxamide

Guidance literature:: carbonylbis(triphenylphosphine)rhodium⁽¹⁾chloride; In tetrahydrofuran; at 20 ℃; for 3h; Inert atmosphere;

Reference yield:

: 347886-00-4
[2-(bromomethyl)prop-2-en-1-yloxy]methylbenzene

: 1378429-59-4
6-(N-(3-(benzyloxy)-2-((4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methyl)propyl)methylsulfonamido)-5-cyclopropyl-N-ethyl-2-(4-fluorophenyl)benzofuran-3-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 0.5 h / Inert atmosphere; Reflux

2: carbonylbis(triphenylphosphine)rhodium⁽¹⁾chloride / tetrahydrofuran / 3 h / 20 °C / Inert atmosphere

With potassium carbonate; potassium iodide; carbonylbis(triphenylphosphine)rhodium⁽¹⁾chloride; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 113964-32-2
1-{[2-((chloromethyl)allyl)oxy]methyl}-4-methoxybenzene

: 1378429-59-4
6-(N-(3-(benzyloxy)-2-((4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methyl)propyl)methylsulfonamido)-5-cyclopropyl-N-ethyl-2-(4-fluorophenyl)benzofuran-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: lithium bromide / tetrahydrofuran / 2 h / 60 °C

2: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 0.5 h / Inert atmosphere; Reflux

3: carbonylbis(triphenylphosphine)rhodium⁽¹⁾chloride / tetrahydrofuran / 3 h / 20 °C / Inert atmosphere

With potassium carbonate; potassium iodide; lithium bromide; carbonylbis(triphenylphosphine)rhodium⁽¹⁾chloride; In tetrahydrofuran; N,N-dimethyl-formamide;