2-bromo-1-[3-morpholin-4-yl-5-(pentafluorosulfanyl)phenyl]ethanone

Base Information

Chemical Name:2-bromo-1-[3-morpholin-4-yl-5-(pentafluorosulfanyl)phenyl]ethanone
CAS No.:1178584-32-1
Molecular Formula:C₁₂H₁₃BrF₅NO₂S
Molecular Weight:410.203
Hs Code.:

Synonyms:2-bromo-1-[3-morpholin-4-yl-5-(pentafluorosulfanyl)phenyl]ethanone

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Chemical Property of 2-bromo-1-[3-morpholin-4-yl-5-(pentafluorosulfanyl)phenyl]ethanone

Chemical Property:

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Technology Process of 2-bromo-1-[3-morpholin-4-yl-5-(pentafluorosulfanyl)phenyl]ethanone

There total 7 articles about 2-bromo-1-[3-morpholin-4-yl-5-(pentafluorosulfanyl)phenyl]ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1178584-78-5
1-[3-morpholin-4-yl-5-(pentafluorosulfanyl)phenyl]ethanone

: 1178584-32-1
2-bromo-1-[3-morpholin-4-yl-5-(pentafluorosulfanyl)phenyl]ethanone

Guidance literature:: With phenyltrimethylammonium tribromide; In tetrahydrofuran; methanol; at 20 ℃; for 27h;

Reference yield:

: 833-96-5
3-(pentafluoro-λ⁶-sulphanyl)benzoic acid

: 1178584-32-1
2-bromo-1-[3-morpholin-4-yl-5-(pentafluorosulfanyl)phenyl]ethanone

Guidance literature:: Multi-step reaction with 7 steps

1.1: nitric acid; sulfuric acid / 20 - 75 °C / Inert atmosphere

2.1: thionyl chloride / 10 h / Reflux; Inert atmosphere

3.1: N,N-diethyl-N-isopropylamine / dichloromethane / 1 h / 20 - 25 °C / Inert atmosphere

4.1: hydrogen / Raney nickel / methanol / 5 h / Inert atmosphere

5.1: caesium carbonate / sodium iodide / N,N-dimethyl-formamide / 3 h / 130 °C / microwave irradiation; Inert atmosphere

6.1: diethyl ether; tetrahydrofuran / 0 - 25 °C / Inert atmosphere

7.1: phenyltrimethylammonium tribromide / tetrahydrofuran; methanol / 27 h / 20 - 25 °C / Inert atmosphere

7.2: 24 h / 20 - 25 °C / Inert atmosphere

With thionyl chloride; N,N-diethyl-N-isopropylamine; sulfuric acid; hydrogen; nitric acid; phenyltrimethylammonium tribromide; caesium carbonate; sodium iodide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 852469-45-5
3-nitro-5-(pentafluoro-λ⁶-sulfanyl)benzoic acid

: 1178584-32-1
2-bromo-1-[3-morpholin-4-yl-5-(pentafluorosulfanyl)phenyl]ethanone

Guidance literature:: Multi-step reaction with 6 steps

1.1: thionyl chloride / 10 h / Reflux; Inert atmosphere

2.1: N,N-diethyl-N-isopropylamine / dichloromethane / 1 h / 20 - 25 °C / Inert atmosphere

3.1: hydrogen / Raney nickel / methanol / 5 h / Inert atmosphere

4.1: caesium carbonate / sodium iodide / N,N-dimethyl-formamide / 3 h / 130 °C / microwave irradiation; Inert atmosphere

5.1: diethyl ether; tetrahydrofuran / 0 - 25 °C / Inert atmosphere

6.1: phenyltrimethylammonium tribromide / tetrahydrofuran; methanol / 27 h / 20 - 25 °C / Inert atmosphere

6.2: 24 h / 20 - 25 °C / Inert atmosphere

With thionyl chloride; N,N-diethyl-N-isopropylamine; hydrogen; phenyltrimethylammonium tribromide; caesium carbonate; sodium iodide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide;