Technology Process of (2H)-pyrazole-3,4-dicarboxylic acid 4-[(2-fluoroethyl)methylamide] 3-[(2-phenyl-[1,2,4]triazolo[1,5-a]pyridin-7-yl)amide]
There total 6 articles about (2H)-pyrazole-3,4-dicarboxylic acid 4-[(2-fluoroethyl)methylamide] 3-[(2-phenyl-[1,2,4]triazolo[1,5-a]pyridin-7-yl)amide] which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: oxalyl dichloride / 2 h / 50 °C
2: pyridine / 0.17 h / 0 - 25 °C
3: lithium hydroxide monohydrate / tetrahydrofuran / 2 h / 0 - 25 °C
4: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 16 h / 0 - 25 °C
5: boron tribromide / dichloromethane / 0.5 h / 0 °C / Inert atmosphere
With
pyridine; oxalyl dichloride; lithium hydroxide monohydrate; boron tribromide; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 7 steps
1: hydrogenchloride / ethanol; water / 12 h / 25 °C
2: lithium hydroxide monohydrate / tetrahydrofuran; methanol / 1 h / 0 - 25 °C
3: oxalyl dichloride / 2 h / 50 °C
4: pyridine / 0.17 h / 0 - 25 °C
5: lithium hydroxide monohydrate / tetrahydrofuran / 2 h / 0 - 25 °C
6: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 16 h / 0 - 25 °C
7: boron tribromide / dichloromethane / 0.5 h / 0 °C / Inert atmosphere
With
pyridine; hydrogenchloride; oxalyl dichloride; lithium hydroxide monohydrate; boron tribromide; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: lithium hydroxide monohydrate / tetrahydrofuran / 2 h / 0 - 25 °C
2: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 16 h / 0 - 25 °C
3: boron tribromide / dichloromethane / 0.5 h / 0 °C / Inert atmosphere
With
lithium hydroxide monohydrate; boron tribromide; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
