α-acetoxy-4-<<(dimethylamino)methylene>amino>-α,3,5-trimethylbenzeneacetic acid ethyl ester

Base Information

Chemical Name:α-acetoxy-4-<<(dimethylamino)methylene>amino>-α,3,5-trimethylbenzeneacetic acid ethyl ester
CAS No.:114886-18-9
Molecular Formula:C₁₈H₂₆N₂O₄
Molecular Weight:334.415
Hs Code.:

Synonyms:α-acetoxy-4-<<(dimethylamino)methylene>amino>-α,3,5-trimethylbenzeneacetic acid ethyl ester

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Chemical Property of α-acetoxy-4-<<(dimethylamino)methylene>amino>-α,3,5-trimethylbenzeneacetic acid ethyl ester

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Technology Process of α-acetoxy-4-<<(dimethylamino)methylene>amino>-α,3,5-trimethylbenzeneacetic acid ethyl ester

There total 4 articles about α-acetoxy-4-<<(dimethylamino)methylene>amino>-α,3,5-trimethylbenzeneacetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 108-24-7
acetic anhydride

: 114886-16-7
4-<<(dimethylamino)methylene>amino>-α-hydroxy-α,3,5-trimethylbenzeneacetic acid ethyl ester

: 114886-18-9
α-acetoxy-4-<<(dimethylamino)methylene>amino>-α,3,5-trimethylbenzeneacetic acid ethyl ester

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 0 ℃; for 7h; Yield given;
DOI:10.1021/jm00117a023

Reference yield:

: 617-35-6
2-oxo-propionic acid ethyl ester

: 114886-18-9
α-acetoxy-4-<<(dimethylamino)methylene>amino>-α,3,5-trimethylbenzeneacetic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 51.8 percent / n-BuLi, LiBr / tetrahydrofuran; hexane / 0.25 h / -78 °C

2: 4-(dimethylamino)pyridine, Et₃N / CH₂Cl₂ / 7 h / 0 °C

With dmap; n-butyllithium; triethylamine; lithium bromide; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/jm00117a023

Reference yield:

: 24596-19-8
4-bromo-2,6-dimethylphenylamine

: 114886-18-9
α-acetoxy-4-<<(dimethylamino)methylene>amino>-α,3,5-trimethylbenzeneacetic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 96.2 percent / 192 h / Heating

2: 51.8 percent / n-BuLi, LiBr / tetrahydrofuran; hexane / 0.25 h / -78 °C

3: 4-(dimethylamino)pyridine, Et₃N / CH₂Cl₂ / 7 h / 0 °C

With dmap; n-butyllithium; triethylamine; lithium bromide; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/jm00117a023