N⁽¹⁾,N⁽⁸⁾-bis(4-amino-1-(4-(aminomethyl)benzyl)-2-butyl-1H-imidazo[4,5-c]quinolin-8-yl)octanediamide

Base Information

• Chemical Name: N⁽¹⁾,N⁽⁸⁾-bis(4-amino-1-(4-(aminomethyl)benzyl)-2-butyl-1H-imidazo[4,5-c]quinolin-8-yl)octanediamide
• CAS No.: 1357308-75-8
• Molecular Formula: C₅₂H₆₂N₁₂O₂
• Molecular Weight: 887.143

Synonyms:N⁽¹⁾,N⁽⁸⁾-bis(4-amino-1-(4-(aminomethyl)benzyl)-2-butyl-1H-imidazo[4,5-c]quinolin-8-yl)octanediamide

Chemical Property of N⁽¹⁾,N⁽⁸⁾-bis(4-amino-1-(4-(aminomethyl)benzyl)-2-butyl-1H-imidazo[4,5-c]quinolin-8-yl)octanediamide

Chemical Property:

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Technology Process of N⁽¹⁾,N⁽⁸⁾-bis(4-amino-1-(4-(aminomethyl)benzyl)-2-butyl-1H-imidazo[4,5-c]quinolin-8-yl)octanediamide

There total 5 articles about N⁽¹⁾,N⁽⁸⁾-bis(4-amino-1-(4-(aminomethyl)benzyl)-2-butyl-1H-imidazo[4,5-c]quinolin-8-yl)octanediamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C62H78N12O6 → N(1),N(8)-bis(4-amino-1-(4-(aminomethyl)benzyl)-2-butyl-1H-imidazo[4,5-c]quinolin-8-yl)octanediamide (1357308-75-8)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; for 14h;

DOI:10.1021/jm2010207

Reference yield:

1-[[4-(aminomethyl)phenyl]methyl]-2-butyl-1H-imidazo[4,5-c]quinolin-4-amine (1258457-59-8) → N(1),N(8)-bis(4-amino-1-(4-(aminomethyl)benzyl)-2-butyl-1H-imidazo[4,5-c]quinolin-8-yl)octanediamide (1357308-75-8)

Guidance literature:

Multi-step reaction with 5 steps

1: sulfuric acid; nitric acid / 12 h

2: methanol / 0.5 h

3: hydrogen / methanol / 3102.97 Torr

4: triethylamine / tetrahydrofuran / 1 h

5: hydrogenchloride / 1,4-dioxane / 14 h

With hydrogenchloride; sulfuric acid; hydrogen; nitric acid; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol;

DOI:10.1021/jm2010207

Reference yield:

tert-butyl 4-((4-amino-2-butyl-8-nitro-1H-imidazo[4,5-c]quinolin-1-yl)methyl)benzylcarbamate (1357308-58-7) → N(1),N(8)-bis(4-amino-1-(4-(aminomethyl)benzyl)-2-butyl-1H-imidazo[4,5-c]quinolin-8-yl)octanediamide (1357308-75-8)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogen / methanol / 3102.97 Torr

2: triethylamine / tetrahydrofuran / 1 h

3: hydrogenchloride / 1,4-dioxane / 14 h

With hydrogenchloride; hydrogen; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol;

DOI:10.1021/jm2010207

upstream raw materials:

1-[[4-(aminomethyl)phenyl]methyl]-2-butyl-1H-imidazo[4,5-c]quinolin-4-amine

tert-butyl 4-((4-amino-2-butyl-8-nitro-1H-imidazo[4,5-c]quinolin-1-yl)methyl)benzylcarbamate

1-(4-(aminomethyl)benzyl)-2-butyl-8-nitro-1H-imidazo[4,5-c]quinolin-4-amine

tert-butyl 4-((4,8-diamino-2-butyl-1H-imidazo[4,5-c]quinolin-1-yl)methyl)benzylcarbamate

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