(+)-1-[3,5-bis(trifluoromethyl)benzoyl]-2-(phenylmethyl)-4-piperidinone

Base Information

Chemical Name:(+)-1-[3,5-bis(trifluoromethyl)benzoyl]-2-(phenylmethyl)-4-piperidinone
CAS No.:717927-37-2
Molecular Formula:C₂₁H₁₇F₆NO₂
Molecular Weight:429.362
Hs Code.:

Synonyms:(+)-1-[3,5-bis(trifluoromethyl)benzoyl]-2-(phenylmethyl)-4-piperidinone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (+)-1-[3,5-bis(trifluoromethyl)benzoyl]-2-(phenylmethyl)-4-piperidinone

Chemical Property:

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Technology Process of (+)-1-[3,5-bis(trifluoromethyl)benzoyl]-2-(phenylmethyl)-4-piperidinone

There total 13 articles about (+)-1-[3,5-bis(trifluoromethyl)benzoyl]-2-(phenylmethyl)-4-piperidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 190964-86-4
(+/-)-1-[3,5-bis-(trifluoromethyl)benzoyl]-2-(phenylmethyl)-4-piperidinone

: 717927-38-3
(S)-1-[3,5-bis(trifluoromethyl)benzoyl]-2-(phenylmethyl)-4-piperidinone

: 717927-37-2
(+)-1-[3,5-bis(trifluoromethyl)benzoyl]-2-(phenylmethyl)-4-piperidinone

Guidance literature:: Purification / work up; Resolution of racemate;

Reference yield:

: 7-(phenylmethyl)-1,4-dioxa-8-azaspiro[4.5]decane

: 785-56-8
3,5-bis(trifluoromethyl)phenyl carboxylic acid chloride

: 717927-37-2
(+)-1-[3,5-bis(trifluoromethyl)benzoyl]-2-(phenylmethyl)-4-piperidinone

Guidance literature:: 7-(phenylmethyl)-1,4-dioxa-8-azaspiro[4.5]decane; 3,5-bis(trifluoromethyl)phenyl carboxylic acid chloride; With triethylamine; at 15 - 30 ℃; for 0.5h; Inert atmosphere;

With hydrogenchloride; In ethanol; water; at 60 ℃; for 16h; Inert atmosphere;
DOI:10.1021/op700086d

Reference yield:

: (±)-tetrahydro-1'-phenylspiro(1,3-dioxolan-2,7'(8′H)-3Hoxazolo[3,4-a]pyridin)-3′-one

: 717927-37-2
(+)-1-[3,5-bis(trifluoromethyl)benzoyl]-2-(phenylmethyl)-4-piperidinone

Guidance literature:: Multi-step reaction with 3 steps

1.1: methanol / 0.25 h / Reflux; Inert atmosphere

2.1: sodium hydroxide / Inert atmosphere

3.1: triethylamine / 0.5 h / 15 - 30 °C / Inert atmosphere

3.2: 16 h / 60 °C / Inert atmosphere

With triethylamine; sodium hydroxide; In methanol;
DOI:10.1021/op700086d