[2'-(tert-butyl-diphenyl-silanyloxymethyl)-biphenyl-3-yl]-methanol

Base Information

• Chemical Name: [2'-(tert-butyl-diphenyl-silanyloxymethyl)-biphenyl-3-yl]-methanol
• CAS No.: 691407-89-3
• Molecular Formula: C₃₀H₃₂O₂Si
• Molecular Weight: 452.668
• Mol file: 691407-89-3.mol

Synonyms:[2'-(tert-butyl-diphenyl-silanyloxymethyl)-biphenyl-3-yl]-methanol

Chemical Property of [2'-(tert-butyl-diphenyl-silanyloxymethyl)-biphenyl-3-yl]-methanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [2'-(tert-butyl-diphenyl-silanyloxymethyl)-biphenyl-3-yl]-methanol

There total 3 articles about [2'-(tert-butyl-diphenyl-silanyloxymethyl)-biphenyl-3-yl]-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

(2-Bromo-benzyloxy)-tert-butyl-diphenyl-silane (132286-87-4) + [3-(hydroxymethyl)phenyl]boronic acid (87199-15-3) → [2'-(tert-butyl-diphenyl-silanyloxymethyl)-biphenyl-3-yl]-methanol (691407-89-3)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 16h;

DOI:10.1021/ja049873+

Reference yield:

o-bromobenzyl alcohol (18982-54-2) → [2'-(tert-butyl-diphenyl-silanyloxymethyl)-biphenyl-3-yl]-methanol (691407-89-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / imidazole / dimethylformamide / 24 h / 20 °C

2: 94 percent / Pd(PPh₃)4; aq. Cs₂CO₃ / dimethylformamide / 16 h / 100 °C

With 1H-imidazole; tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; In N,N-dimethyl-formamide; 2: Suzuki coupling;

DOI:10.1021/ja049873+

Reference yield:

tert-butylchlorodiphenylsilane (58479-61-1) → [2'-(tert-butyl-diphenyl-silanyloxymethyl)-biphenyl-3-yl]-methanol (691407-89-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / imidazole / dimethylformamide / 24 h / 20 °C

2: 94 percent / Pd(PPh₃)4; aq. Cs₂CO₃ / dimethylformamide / 16 h / 100 °C

With 1H-imidazole; tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; In N,N-dimethyl-formamide; 2: Suzuki coupling;

DOI:10.1021/ja049873+

upstream raw materials:

(2-Bromo-benzyloxy)-tert-butyl-diphenyl-silane

[3-(hydroxymethyl)phenyl]boronic acid

o-bromobenzyl alcohol

tert-butylchlorodiphenylsilane

Downstream raw materials:

(CH₃)2(C₆H₅)4C₅H₂O₄POCH₂C₆H₄C₆H₄CH₂CH(C₃H₃NOC₆H₅)2

(CH₃)2(C₆H₅)4C₅H₂O₄POCH₂C₆H₄C₆H₄CH₂CH(C₃H₃NOC₆H₅)2

C₄₉H₄₈N₂O₃Si

C₄₉H₄₈N₂O₃Si