2-(4-(3-((1-ethylpiperidin-4-yl)methoxy)-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridin-4-yloxy)-3-fluorophenylamino)-N-(4-fluorophenyl)nicotinamide

Base Information

Chemical Name:2-(4-(3-((1-ethylpiperidin-4-yl)methoxy)-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridin-4-yloxy)-3-fluorophenylamino)-N-(4-fluorophenyl)nicotinamide
CAS No.:1129458-85-0
Molecular Formula:C₄₀H₃₉F₂N₇O₄
Molecular Weight:719.791
Hs Code.:

2-(4-(3-((1-ethylpiperidin-4-yl)methoxy)-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridin-4-yloxy)-3-fluorophenylamino)-N-(4-fluorophenyl)nicotinamide

Synonyms:2-(4-(3-((1-ethylpiperidin-4-yl)methoxy)-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridin-4-yloxy)-3-fluorophenylamino)-N-(4-fluorophenyl)nicotinamide

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Chemical Property of 2-(4-(3-((1-ethylpiperidin-4-yl)methoxy)-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridin-4-yloxy)-3-fluorophenylamino)-N-(4-fluorophenyl)nicotinamide

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Technology Process of 2-(4-(3-((1-ethylpiperidin-4-yl)methoxy)-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridin-4-yloxy)-3-fluorophenylamino)-N-(4-fluorophenyl)nicotinamide

There total 1 articles about 2-(4-(3-((1-ethylpiperidin-4-yl)methoxy)-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridin-4-yloxy)-3-fluorophenylamino)-N-(4-fluorophenyl)nicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

: 1129458-82-7
2-(3-fluoro-4-(1-(4-methoxybenzyl)-3-(piperidin-4-ylmethoxy)-1H-pyrazolo[3,4-b]pyridin-4-yloxy)phenylamino)-N-(4-fluorophenyl)nicotinamide

: 75-07-0,9002-91-9
acetaldehyde

: 1129458-85-0
2-(4-(3-((1-ethylpiperidin-4-yl)methoxy)-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridin-4-yloxy)-3-fluorophenylamino)-N-(4-fluorophenyl)nicotinamide

Guidance literature:: 2-(3-fluoro-4-(1-(4-methoxybenzyl)-3-(piperidin-4-ylmethoxy)-1H-pyrazolo[3,4-b]pyridin-4-yloxy)phenylamino)-N-(4-fluorophenyl)nicotinamide; acetaldehyde; With sodium tris(acetoxy)borohydride; In dichloromethane; at 20 ℃; for 1h;

With water; In dichloromethane;

Reference yield:

: 1129458-85-0
2-(4-(3-((1-ethylpiperidin-4-yl)methoxy)-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridin-4-yloxy)-3-fluorophenylamino)-N-(4-fluorophenyl)nicotinamide

: 1129457-38-0
2-(4-(3-((1-ethylpiperidin-4-yl)methoxy)-1H-pyrazolo[3,4-b]pyridin-4-yloxy)-3-fluorophenylamino)-N-(4-fluorophenyl)nicotinamide

Guidance literature:: 2-(4-(3-((1-ethylpiperidin-4-yl)methoxy)-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridin-4-yloxy)-3-fluorophenylamino)-N-(4-fluorophenyl)nicotinamide; With trifluoroacetic acid; at 75 ℃; for 18h;

With water; sodium carbonate; at 20 ℃;