7-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4,7-diazaspiro[2.5]octane-4-sulfonic acid (3-cyano-propyl)-(3-phenyl-propyl)-amide

Base Information

Chemical Name:7-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4,7-diazaspiro[2.5]octane-4-sulfonic acid (3-cyano-propyl)-(3-phenyl-propyl)-amide
CAS No.:1384874-20-7
Molecular Formula:C₂₅H₃₁N₇O₂S
Molecular Weight:493.633
Hs Code.:

Synonyms:7-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4,7-diazaspiro[2.5]octane-4-sulfonic acid (3-cyano-propyl)-(3-phenyl-propyl)-amide

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Chemical Property of 7-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4,7-diazaspiro[2.5]octane-4-sulfonic acid (3-cyano-propyl)-(3-phenyl-propyl)-amide

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Technology Process of 7-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4,7-diazaspiro[2.5]octane-4-sulfonic acid (3-cyano-propyl)-(3-phenyl-propyl)-amide

There total 6 articles about 7-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4,7-diazaspiro[2.5]octane-4-sulfonic acid (3-cyano-propyl)-(3-phenyl-propyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₀H₃₉N₇O₄S

: 1384874-20-7
7-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4,7-diazaspiro[2.5]octane-4-sulfonic acid (3-cyano-propyl)-(3-phenyl-propyl)-amide

Guidance literature:: With trifluoroacetic acid; In tetrahydrofuran; at 20 ℃; for 2h;

Reference yield:

: 3680-69-1
4-chloro-1H-pyrrolo[2,3-d]pyrimidine

: 1384874-20-7
7-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4,7-diazaspiro[2.5]octane-4-sulfonic acid (3-cyano-propyl)-(3-phenyl-propyl)-amide

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / water / 16 h / 100 °C

2.1: ammonium formate / palladium 10% on activated carbon / methanol / 0.5 h / Reflux

2.2: 0.25 h

3.1: SULFAMIDE / 1,4-dioxane / 6 h / Reflux

4.1: caesium carbonate / N,N-dimethyl-formamide / 16 h / 0 - 20 °C

5.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 0 - 20 °C

6.1: caesium carbonate / acetonitrile / 88 h / 20 °C

7.1: trifluoroacetic acid / tetrahydrofuran / 2 h / 20 °C

With ammonium formate; potassium carbonate; SULFAMIDE; caesium carbonate; trifluoroacetic acid; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1261358-78-4
4-(4-benzyl-4,7-diaza-spiro[2.5]oct-7-yl)-7H-pyrrolo[2,3-d]pyrimidine

: 1384874-20-7
7-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4,7-diazaspiro[2.5]octane-4-sulfonic acid (3-cyano-propyl)-(3-phenyl-propyl)-amide

Guidance literature:: Multi-step reaction with 6 steps

1.1: ammonium formate / palladium 10% on activated carbon / methanol / 0.5 h / Reflux

1.2: 0.25 h

2.1: SULFAMIDE / 1,4-dioxane / 6 h / Reflux

3.1: caesium carbonate / N,N-dimethyl-formamide / 16 h / 0 - 20 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 0 - 20 °C

5.1: caesium carbonate / acetonitrile / 88 h / 20 °C

6.1: trifluoroacetic acid / tetrahydrofuran / 2 h / 20 °C

With ammonium formate; potassium carbonate; SULFAMIDE; caesium carbonate; trifluoroacetic acid; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide; acetonitrile;